1- (3,5,5,8,8- pentamethyl- 5,6,7,8- tetrahydro- 2- naphthyl)- 1H- benzotriazole- 5- carboxylic acid

a partial RXR agonist; structure in first source

Also Known As:

CBt-PMN

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Tetrahydronaphthalenes: 1
        1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid: 5
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Tetrahydronaphthalenes: 1
      - 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid: 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid: 5

Experts

1.	Kakuta, Hiroki: 5 articles (01/2019 - 05/2012)
2.	Makishima, Makoto: 3 articles (01/2019 - 05/2012)
3.	Shibahara, Osamu: 3 articles (01/2019 - 01/2017)
4.	Yamada, Shoya: 3 articles (01/2017 - 05/2012)
5.	Fujihara, Michiko: 2 articles (01/2019 - 01/2019)
6.	Watanabe, Masaki: 2 articles (01/2019 - 01/2017)
7.	Fujiwara, Chisa: 2 articles (03/2013 - 05/2012)
8.	Hagaya, Manabu: 2 articles (03/2013 - 05/2012)
9.	Kawata, Kohei: 2 articles (03/2013 - 05/2012)
10.	Nakayama, Mariko: 2 articles (03/2013 - 05/2012)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 03/14/2013 - "We have reported that retinoid X receptor (RXR) partial agonist 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid (CBt-PMN, 4a) shows a significant antidiabetes effect in the KK-A(y) type 2 diabetes model mice, with reduced side effects compared to RXR full agonists. " 05/10/2012 - "RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists." 01/01/2019 - "1-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino]benzotriazole-5-carboxylic acid (CBt-PMN), a partial agonist of retinoid X receptor (RXR), has attracted attention due to its potential to treat type 2 diabetes and central nervous system diseases with reduced adverse effects of existing full agonists. "
2.	Central Nervous System Diseases (CNS Diseases) 01/01/2019 - "1-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino]benzotriazole-5-carboxylic acid (CBt-PMN), a partial agonist of retinoid X receptor (RXR), has attracted attention due to its potential to treat type 2 diabetes and central nervous system diseases with reduced adverse effects of existing full agonists. " 01/01/2017 - "The retinoid X receptor (RXR) partial agonist 1-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)amino]benzotriazole-5-carboxylic acid (1; CBt-PMN, Emax = 75%, EC50 = 143 nM) is a candidate for treatment of central nervous system (CNS) diseases such as Alzheimer's and Parkinson's diseases based on reports that RXR-full agonist 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) shows therapeutic effects on these disease in rodent models. "
3.	Colitis 01/01/2019 - "Administration of CBt-PMN efficiently ameliorated the symptoms of colitis. " 01/01/2019 - "We therefore took advantage of a partial RXR agonist, CBt-PMN, to minimize the adverse effects, and evaluated its efficacy in dextran sodium sulfate-induced colitis. "

Related Drugs and Biologics

1.	Retinoid X Receptors (Retinoid X Receptor)
2.	Therapeutic Uses
3.	Carboxylic Acids
4.	benzotriazole
5.	Benzoic Acid (Potassium Benzoate)
6.	Dextrans (Dextran)
7.	Bexarotene (LGD1069)
8.	sodium sulfate (sodium bisulfate)