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2,4-bis(p-hydroxyphenyl)-2-butenal

has antineoplastic activity

Also Known As:

HPB242

Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Aldehydes: 2153
  - 2,4-bis(p-hydroxyphenyl)-2-butenal: 5
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        2,4-bis(p-hydroxyphenyl)-2-butenal: 5

Experts

1.	Hong, Jin Tae: 4 articles (04/2014 - 10/2011)
2.	Han, Sang Bae: 2 articles (04/2014 - 10/2011)
3.	Jin, Peng: 2 articles (04/2014 - 01/2013)
4.	Shim, Jung-Hyun: 2 articles (01/2014 - 01/2012)
5.	Choi, Dong-Young: 2 articles (01/2013 - 10/2011)
6.	Lee, Young-Jung: 2 articles (01/2013 - 10/2011)
7.	Ham, Young Wan: 1 article (04/2014)
8.	Han, Jin Yi: 1 article (04/2014)
9.	Jung, Heon-Sang: 1 article (04/2014)
10.	Kim, Jin A: 1 article (04/2014)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 01/05/2013 - "Anti-inflammatory and anti-amyloidogenic effects of a small molecule, 2,4-bis(p-hydroxyphenyl)-2-butenal in Tg2576 Alzheimer's disease mice model." 10/07/2011 - "These results indicate that 2,4-bis(p-hydroxyphenyl)-2-butenal inhibits neuroinflammatory reactions and amyloidogenesis through inhibition of NF-κB and STAT3 activation, and suggest that 2,4-bis(p-hydroxyphenyl)-2-butenal may be useful for the treatment of neuroinflammatory diseases like Alzheimer's disease."
2.	Neuroinflammatory Diseases 10/07/2011 - "These results indicate that 2,4-bis(p-hydroxyphenyl)-2-butenal inhibits neuroinflammatory reactions and amyloidogenesis through inhibition of NF-κB and STAT3 activation, and suggest that 2,4-bis(p-hydroxyphenyl)-2-butenal may be useful for the treatment of neuroinflammatory diseases like Alzheimer's disease." 10/07/2011 - "Further, 2,4-bis(p-hydroxyphenyl)-2-butenal inhibited the transcriptional and DNA binding activity of NF-κB--a transcription factor that regulates genes involved in neuroinflammation and amyloidogenesis via inhibition of IκB degradation as well as nuclear translocation of p50 and p65. " 04/01/2014 - "2,4-Bis(p-hydroxyphenyl)-2-butenal (Butenal), a tyrosine-fructose Maillard reaction product has been demonstrated as an effective compound for prevention of neuroinflammatory diseases. "
3.	Squamous Cell Carcinoma of Head and Neck 01/15/2014 - "The purpose of this study was to investigate the anti-proliferative effects of 2,4-bis (p-hydroxyphenyl)-2-butenal (HPB242) on two oral squamous cell carcinoma (OSCC) cell lines, HN22 and HSC4, through regulation of specificity protein 1 (Sp1). "
4.	Neoplasms (Cancer) 01/15/2014 - "Maillard reaction products (MRPs) have antioxidant, antimutagenic, and antibacterial effects though 2,4-bis (p-hydroxyphenyl)-2-butenal (HPB242), a fructose-tyrosine MRP, appears to inhibit proliferation of cancer cells, its mechanism of action has not been studied in detail. " 01/01/2012 - "Maillard reaction products (MRPs) have antioxidant, antimutagenic, and antibacterial effects, and although 2,4-bis (p-hydroxyphenyl)-2-butenal (HPB242), a fructose-tyrosine MRP, appears to inhibit proliferation of cancer cells, its mechanism of action has not been studied in detail. "
5.	Cognitive Dysfunction 01/05/2013 - "Treatment of HPB242 (5 mg/kg for 1 month) significantly attenuated cognitive impairments in Tg2576 transgenic mice. "

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4.	Fructose
5.	Antioxidants
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