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PDA-66

has antineoplastic activity; structure in first source

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Beller, Matthias: 4 articles (01/2020 - 03/2013)
2.	Junghanss, Christian: 4 articles (01/2020 - 03/2013)
3.	Pews-Davtyan, Anahit: 4 articles (01/2020 - 03/2013)
4.	Rolfs, Arndt: 4 articles (01/2020 - 03/2013)
5.	Roolf, Catrin: 3 articles (01/2020 - 02/2014)
6.	Beck, Julia: 2 articles (01/2020 - 06/2016)
7.	Brenig, Bertram: 2 articles (01/2020 - 06/2016)
8.	Murua Escobar, Hugo: 2 articles (01/2020 - 06/2016)
9.	Nolte, Ingo: 2 articles (01/2020 - 06/2016)
10.	Schütz, Ekkehard: 2 articles (01/2020 - 06/2016)

Related Diseases

1.	Neoplasms (Cancer) 03/15/2013 - "In this study we describe the effect of PDA-66, a newly synthesised indolylmaleimide, showing a strong dose dependent anti-proliferative effect on immortalised human progenitor and cancer cells. " 01/01/2020 - "Herein, a comparative characterization of PDA-66 and PDA-377 mediated effects was performed in human and canine PCa cell lines, which is also the first detailed characterization of these agents on cells derived from solid tumors in general. " 03/15/2013 - "To prove a potential anti-cancer activity of PDA-66 we examined the effect of PDA-66 on human SH-SY5Y neuroblastoma and A-459 lung cancer cells, showing a significant reduction in cancer cell proliferation in a dose dependent manner. " 03/15/2013 - "Thus PDA-66 is a new anti-mitotic compound with an indole-core with the potential to be used for cancer therapy."
2.	Neuroblastoma 03/15/2013 - "To prove a potential anti-cancer activity of PDA-66 we examined the effect of PDA-66 on human SH-SY5Y neuroblastoma and A-459 lung cancer cells, showing a significant reduction in cancer cell proliferation in a dose dependent manner. "
3.	Lung Neoplasms (Lung Cancer) 03/15/2013 - "To prove a potential anti-cancer activity of PDA-66 we examined the effect of PDA-66 on human SH-SY5Y neuroblastoma and A-459 lung cancer cells, showing a significant reduction in cancer cell proliferation in a dose dependent manner. "
4.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 02/06/2014 - "The novel arylindolylmaleimide PDA-66 displays pronounced antiproliferative effects in acute lymphoblastic leukemia cells."
5.	B-Cell Lymphoma (Lymphoma, B Cell) 06/07/2016 - ", the two arylindolylmaleimide derivatives PDA-66 and PDA-377 were evaluated as potential chemotherapeutic agents on canine B-cell lymphoma cell lines. "

Related Drugs and Biologics

1.	indole

Related Therapies and Procedures

1.	Therapeutics