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((2- hydroxy- 4- oxo- 6,7,8,9- tetrahydro- 4H,5H- 10- thia- 1,4a- diazabenzo(a)azulene- 3- carbonyl)amino)acetic acid

inhibits hypoxia-inducible factor hydroxylase

Also Known As:

TRC160334

Networked: 2 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Glycine: 5151
    - ((2-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H,5H-10-thia-1,4a-diazabenzo(a)azulene-3-carbonyl)amino)acetic acid: 2
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - ((2-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H,5H-10-thia-1,4a-diazabenzo(a)azulene-3-carbonyl)amino)acetic acid: 2

Experts

1.	Deshpande, Shailesh: 2 articles (01/2014 - 01/2012)
2.	Chaudhary, Anita R: 1 article (01/2014)
3.	Chauthaiwale, Vijay: 1 article (01/2014)
4.	Dutt, Chaitanya: 1 article (01/2014)
5.	Gupta, Ram: 1 article (01/2014)
6.	Gupta, Ramesh Chandra: 1 article (01/2014)
7.	Jadhav, Avinash V: 1 article (01/2014)
8.	Shah, Binita N: 1 article (01/2014)
9.	Zambad, Shitalkumar P: 1 article (01/2014)
10.	Chaudhary, Anita: 1 article (01/2012)

Related Diseases

1.	Hypoxia (Hypoxemia) 01/01/2014 - "Therapeutic treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates murine colitis." 01/01/2012 - "Treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates ischemic acute kidney injury."
2.	Colitis 01/01/2014 - "TRC160334 treatment resulted in significant improvement in disease end points in both models of colitis. " 01/01/2014 - "The efficacy of TRC160334 was evaluated in two different mouse models of colitis by oral route. " 01/01/2014 - "In the present study we aim to establish therapeutic efficacy of TRC160334, a novel HIF hydroxylase inhibitor, in animal models of colitis. " 01/01/2014 - "Therapeutic treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates murine colitis."
3.	Acute Kidney Injury (Acute Renal Failure) 01/01/2012 - "Treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates ischemic acute kidney injury."
4.	Ischemia 01/01/2012 - "Efficacy of TRC160334 was evaluated in a rat model of ischemia/reperfusion-induced AKI. " 01/01/2012 - "Two different treatment protocols were employed, one involved treatment with TRC160334 before onset of ischemia, the other involved treatment after the reperfusion of kidneys. "
5.	Body Weight (Weight, Body) 01/01/2014 - "TRC160334 successfully attenuated the rate of fall in body weight, disease activity index, and macroscopic and microscopic scores of colonic damage leading to overall improvement in study outcome. "

Related Drugs and Biologics

1.	Mixed Function Oxygenases (Monooxygenases)