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3',4',5'-trimethoxyflavonol

has anticarcinogenic activity; structure in first source

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavonols: 321
        3',4',5'-trimethoxyflavonol: 6
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavonols: 321
        3',4',5'-trimethoxyflavonol: 6

Experts

1.	Britton, Robert G: 5 articles (07/2015 - 04/2009)
2.	Brown, Karen: 5 articles (07/2015 - 04/2009)
3.	Sale, Stewart: 5 articles (07/2015 - 04/2009)
4.	Steward, William P: 4 articles (12/2012 - 04/2009)
5.	Gescher, Andreas J: 3 articles (07/2015 - 08/2010)
6.	Howells, Lynne M: 2 articles (07/2015 - 08/2010)
7.	Saad, Shaban E A: 2 articles (07/2015 - 12/2012)
8.	Horner-Glister, Emma: 2 articles (12/2012 - 08/2012)
9.	Gescher, Andreas: 2 articles (08/2012 - 04/2009)
10.	Chen, Guanglin: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2012 - "Tissue distribution and metabolism of the putative cancer chemopreventive agent 3',4',5'-trimethoxyflavonol (TMFol) in mice." 12/01/2012 - "3',4',5'-Trimethoxyflavonol (TMFol) is a synthetic flavonol with preclinical cancer chemopreventive properties. " 08/01/2010 - "The hypothesis was tested that a synthetic flavonol, 3',4',5'-trimethoxyflavonol (TMFol), can interfere with tumor development and p53 expression in two models of colorectal carcinogenesis, Apc(Min) mice and human-derived HCT116 adenocarcinoma-bearing nude mice. " 08/01/2012 - "Compounds 3, 8 and 11 (IC(50) 2.6, 3.3 and 4.0 μM respectively) showed potent cancer cell growth inhibition, comparable to the lead compound 3',4',5'-trimethoxyflavonol (1) (IC(50) 3.1 μM) and superior to the naturally occurring flavonols quercetin (16) and fisetin (22) (both >15 μM). "
2.	Colorectal Neoplasms (Colorectal Cancer) 04/01/2009 - "3',4',5'-Trimethoxyflavonol (TMFol) was synthesized as a potential colorectal cancer chemopreventive agent. " 08/01/2010 - "Preclinical colorectal cancer chemopreventive efficacy and p53-modulating activity of 3',4',5'-trimethoxyflavonol, a quercetin analogue."
3.	Prostatic Neoplasms (Prostate Cancer) 01/01/2017 - "Our results indicate that most of them are significantly more potent than the parent 3',4',5'-trimethoxyflavonol in inhibiting the cell proliferation in PC-3 and LNCaP prostate cancer cell models. " 07/01/2015 - "Inhibition of prostate cancer cell growth by 3',4',5'-trimethoxyflavonol (TMFol)."
4.	Carcinogenesis 08/01/2010 - "The hypothesis was tested that a synthetic flavonol, 3',4',5'-trimethoxyflavonol (TMFol), can interfere with tumor development and p53 expression in two models of colorectal carcinogenesis, Apc(Min) mice and human-derived HCT116 adenocarcinoma-bearing nude mice. "
5.	Adenocarcinoma 08/01/2010 - "The hypothesis was tested that a synthetic flavonol, 3',4',5'-trimethoxyflavonol (TMFol), can interfere with tumor development and p53 expression in two models of colorectal carcinogenesis, Apc(Min) mice and human-derived HCT116 adenocarcinoma-bearing nude mice. "

Related Drugs and Biologics

1.	Quercetin
2.	3-hydroxyflavone
3.	Flavonols
4.	fisetin