malleilactone

a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens; structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bouddhara, Tiffany: 1 article (01/2018)
2.	Chandler, Josephine R: 1 article (01/2018)
3.	Deay, Jacqueline: 1 article (01/2018)
4.	Douglas, Justin: 1 article (01/2018)
5.	Gao, Zhe: 1 article (01/2018)
6.	Hursh, Wyatt: 1 article (01/2018)
7.	Klaus, Jennifer R: 1 article (01/2018)
8.	Majerczyk, Charlotte: 1 article (01/2018)
9.	Martins, Patricia: 1 article (01/2018)
10.	Monize, Kyle: 1 article (01/2018)

Related Diseases

1.	Melioidosis 01/01/2018 - "Our studies demonstrate that malleilactone biosynthesis or MalR could be new targets for developing therapeutics to treat melioidosis." 08/15/2012 - "Small molecules targeting malleilactone biosynthesis either alone or in conjunction with antibiotics could prove useful as therapeutics to combat melioidosis and glanders." 01/01/2018 - "pseudomallei virulence factor and provide the foundation for understanding how malleilactone contributes to the pathology of melioidosis infections.IMPORTANCE Many bacterially produced polyketides are cytotoxic to mammalian cells and are potentially important contributors to pathogenesis during infection. "
2.	Infections 01/01/2018 - "pseudomallei virulence factor and provide the foundation for understanding how malleilactone contributes to the pathology of melioidosis infections.IMPORTANCE Many bacterially produced polyketides are cytotoxic to mammalian cells and are potentially important contributors to pathogenesis during infection. "
3.	Glanders 08/15/2012 - "Small molecules targeting malleilactone biosynthesis either alone or in conjunction with antibiotics could prove useful as therapeutics to combat melioidosis and glanders."

Related Drugs and Biologics

1.	Polyketides
2.	Virulence Factors (Pathogenicity Factors)
3.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Therapeutics