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monascuspiloin

an analog of the Monascus pigment monascin from Monascus; has radiation-sensitizing and antineoplastic activities; structure in first source

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - monascuspiloin: 2

Experts

1.	Chen, Yen-Lin: 2 articles (07/2012 - 01/2012)
2.	Wang, Ying-Jan: 2 articles (07/2012 - 01/2012)
3.	Wu, Ming-Der: 2 articles (07/2012 - 01/2012)
4.	Yuan, Gwo-Fang: 2 articles (07/2012 - 01/2012)
5.	Chen, Rong-Jane: 1 article (07/2012)
6.	Hung, Chin-Ming: 1 article (07/2012)
7.	Chiu, Hui-Wen: 1 article (01/2012)
8.	Fang, Wen-Hung: 1 article (01/2012)
9.	Ho, Sheng-Yow: 1 article (01/2012)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 07/25/2012 - "Monascuspiloin induces apoptosis and autophagic cell death in human prostate cancer cells via the Akt and AMPK signaling pathways." 01/01/2012 - "Monascuspiloin enhances the radiation sensitivity of human prostate cancer cells by stimulating endoplasmic reticulum stress and inducing autophagy." 01/01/2012 - "In this study, PC-3 cells (human prostate cancer cells) were used to investigate the anti-cancer effects of ionizing radiation (IR) combined with monascuspiloin (MP, a yellow pigment isolated from Monascus pilosus M93-fermented rice) and to determine the underlying mechanisms of these effects in vitro and in vivo. " 07/25/2012 - "This study is the first to demonstrate that monascuspiloin has therapeutic potential for the treatment of both androgen-dependent and -independent human prostate cancers." 07/25/2012 - "Monascuspiloin effectively inhibits the growth of both androgen-dependent LNCaP and androgen-independent PC-3 human prostate cancer cells. "
2.	Neoplasms (Cancer) 07/25/2012 - "Monascuspiloin inhibits tumor growth in nude mice bearing PC-3 xenografts through induction of apoptosis and autophagy. " 01/01/2012 - "In this study, PC-3 cells (human prostate cancer cells) were used to investigate the anti-cancer effects of ionizing radiation (IR) combined with monascuspiloin (MP, a yellow pigment isolated from Monascus pilosus M93-fermented rice) and to determine the underlying mechanisms of these effects in vitro and in vivo. "

Related Drugs and Biologics

1.	Androgens
2.	monascin