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N- (1- methylethyl)- 5- (pyridin- 4- ylethynyl)pyridine- 2- carboxamide

an mGlu5 agonist

Also Known As:

LSN2463359

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - N-(1-methylethyl)-5-(pyridin-4-ylethynyl)pyridine-2-carboxamide: 1

Experts

1.	Cotel, Marie-Caroline: 1 article (03/2012)
2.	Gastambide, Francois: 1 article (03/2012)
3.	Gilmour, Gary: 1 article (03/2012)
4.	O'Neill, Michael J: 1 article (03/2012)
5.	Robbins, Trevor W: 1 article (03/2012)
6.	Tricklebank, Mark D: 1 article (03/2012)

Related Diseases

1.

Schizophrenia (Dementia Praecox)

03/01/2012 - "Based on the glutamatergic hypothesis of schizophrenia we assessed the effects of a novel mGlu5 positive allosteric modulator, LSN2463359 [N-(1-methylethyl)-5-(pyridin-4-ylethynyl)pyridine-2-carboxamide] on deficits in cognitive flexibility in two distinct rodent models of schizophrenia, the neurodevelopmental MAM E17 model and the acute PCP model. "

Related Drugs and Biologics

1.	pyridine