3'- C- ethynylcytidinylyl- (5'- 1- O)- 2- O- octadecyl- sn- glycerylyl- (3- O- 5')- 2'- deoxy- 5- fluorouridine

has antineoplastic activity; structure in first source

Also Known As:

ECyd-lipid-5-FdU

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleotides: 48
      - Uracil Nucleotides: 40
        Deoxyuracil Nucleotides: 1
        Fluorodeoxyuridylate: 99
        3'-C-ethynylcytidinylyl-(5'-1-O)-2-O-octadecyl-sn-glycerylyl-(3-O-5')-2'-deoxy-5-fluorouridine: 2
      - Cytosine Nucleotides: 10
        Cytidine Monophosphate: 1005
        3'-C-ethynylcytidinylyl-(5'-1-O)-2-O-octadecyl-sn-glycerylyl-(3-O-5')-2'-deoxy-5-fluorouridine: 2
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763

Experts

1.	Schott, Sarah: 2 articles (11/2012 - 06/2011)
2.	Berger, Alexander: 1 article (11/2012)
3.	Busch, Christian: 1 article (11/2012)
4.	Garbe, Claus: 1 article (11/2012)
5.	Ikenberg, Kristian: 1 article (11/2012)
6.	Meier, Friedegund: 1 article (11/2012)
7.	Niessner, Heike: 1 article (11/2012)
8.	Sinnberg, Tobias: 1 article (11/2012)
9.	Venturelli, Sascha: 1 article (11/2012)
10.	Villanueva, Jessie: 1 article (11/2012)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 06/01/2011 - "Additionally, the cytostatic efficacy of 5-FdU(5´-5´)ECyd and ECyd-lipid-5-FdU was evaluated at a minimum of five concentrations at 10 fold dilutions using 60 human tumor cell lines including ovarian and breast cancer cell lines from the National Cancer Institute (USA). "
2.	Ovarian Neoplasms (Ovarian Cancer) 06/01/2011 - "The duplex drugs 5-FdU(5´-5´)ECyd and ECyd-lipid-5-FdU represent potential new chemotherapeutic drugs for breast and ovarian cancer cells which are comparable to currently used drug combinations and more potent in comparison to some monocytostatica used in cancer therapy."
3.	Neoplasms (Cancer) 06/01/2011 - "5-FdU(5´-5´)ECyd and ECyd-lipid-5-FdU have a high cytostatic efficacy reaching 50% tumor cell growth inhibition at concentrations ranging between nano- and micomolar. " 06/01/2011 - "The duplex drugs 5-FdU(5´-5´)ECyd and ECyd-lipid-5-FdU represent potential new chemotherapeutic drugs for breast and ovarian cancer cells which are comparable to currently used drug combinations and more potent in comparison to some monocytostatica used in cancer therapy." 06/01/2011 - "We cultured breast MCF-7, MDA-MB-231 and ovarian OVCAR-29 and OAW-42 cancer cell lines and used the luminometric measuring of the ATP tumor chemosensitivity assay to assess the in vitro activity of 5-FdU(5´-5´)ECyd and ECyd-lipid-5-FdU in comparison to standard single cytostatic agents and combinations thereof currently used in anticancer therapies. "
4.	Melanoma (Melanoma, Malignant) 11/01/2012 - "In vitro (real-time)-proliferation assays demonstrated that 5-FdU(3'-5')ECyd and ECyd-lipid-5-FdU had a high cytotoxic efficacy causing 75% melanoma cell death at concentrations in the nanomolar and micromolar range. "

Related Drugs and Biologics

1.	Cytostatic Agents
2.	Dihydrotachysterol (AT 10)
3.	Drug Combinations
4.	Adenosine Triphosphate (ATP)
5.	2'- deoxy- 5- fluorouridylyl- (3'- 5')- 3'- C- ethynylcytidine

Related Therapies and Procedures

1.	Therapeutics