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5-FdU-alendronate

an antineoplastic antimetabolite; structure in first source

Also Known As:

5-FdU-ale; 5-fluoro-2'-deoxyuridine-alendronate conjugate

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Uracil: 1493
        Fluorouracil: 26711
        5-FdU-alendronate: 3
Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - Organophosphonates: 424
    - Diphosphonates: 11565
      - Alendronate: 2711
        5-FdU-alendronate: 3

Experts

1.	Schem, Christian: 2 articles (03/2017 - 08/2015)
2.	Schott, Sarah: 2 articles (03/2017 - 08/2015)
3.	Tiwari, Sanjay: 2 articles (03/2017 - 08/2015)
4.	Tower, Robert J: 2 articles (03/2017 - 08/2015)
5.	Campbell, Graeme M: 1 article (03/2017)
6.	Damm, Timo: 1 article (03/2017)
7.	Desel, Christine: 1 article (03/2017)
8.	Fuchs, Sabine: 1 article (03/2017)
9.	Glüer, Claus C: 1 article (03/2017)
10.	Heilmann, Thorsten: 1 article (03/2017)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 08/01/2015 - "In vitro and in vivo toxicity of 5-FdU-alendronate, a novel cytotoxic bone-seeking duplex drug against bone metastasis." 08/01/2015 - "In a bone metastasis mouse model, 5-FdU-ale reduced the number of tumor-associated osteoclasts. " 03/01/2017 - "5-FdU-ale, a highly stable conjugate between the antimetabolite 5-fluoro-2'-deoxyuridine and the bisphosphonate alendronate, was tested for its therapeutic efficacy in a mouse model of MDA-MB231 breast cancer bone metastases. "
2.	Breast Neoplasms (Breast Cancer) 08/01/2015 - "The effect of 5-FdU-ale on osteoclast was evaluated with Balb/c nude mice in a metastatic breast cancer mouse model. " 03/01/2017 - "5-FdU-ale, a highly stable conjugate between the antimetabolite 5-fluoro-2'-deoxyuridine and the bisphosphonate alendronate, was tested for its therapeutic efficacy in a mouse model of MDA-MB231 breast cancer bone metastases. "
3.	Weight Loss (Weight Reduction) 08/01/2015 - "5-FdU-ale showed no signs of unwanted side effects, weight loss or nephrotoxicity in mice. "
4.	Neoplasms (Cancer) 08/01/2015 - "In a bone metastasis mouse model, 5-FdU-ale reduced the number of tumor-associated osteoclasts. " 08/01/2015 - "A cell line-specific, dose-related cytotoxicity was observed for 5-FdU-ale in all cancer cell lines tested, which was significantly less toxic than 5-FdU alone when compared to the benign osteoblasts or stromal cells. "
5.	Multiple Myeloma 08/01/2015 - "In vitro cytotoxicity of ale, 5-FdU or 5-FdU-ale was measured with Alamar Blue and MUH cell viability assays in 14 malignant melanoma, multiple myeloma, bone marrow-derived stromal cell and osteoblast-like cell lines. "

Related Drugs and Biologics

1.	Alendronate (Alendronate Sodium)
2.	Diphosphonates (Bisphosphonates)
3.	Antimetabolites
4.	5-fluoro-2'-deoxyuridine
5.	Cytostatic Agents
6.	5-formyl-2'-deoxyuridine
7.	resazurin