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5,6-bis(nitrooxy)hexyl 2-(6-methoxynaphthalen-2-yl)propanoate

Also Known As:

NCX 466

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bani, Daniele: 1 article (05/2012)
2.	Bolla, Manlio: 1 article (05/2012)
3.	Masini, Emanuela: 1 article (05/2012)
4.	Pini, Alessandro: 1 article (05/2012)
5.	Viappiani, Serena: 1 article (05/2012)

Related Diseases

1.	Pneumonia (Pneumonitis) 05/01/2012 - "In conclusion, NCX 466 has shown a significantly higher efficacy than naproxen in reducing lung inflammation and preventing collagen accumulation. "
2.	Fibrosis (Cirrhosis) 05/01/2012 - "In an in vivo mouse model of bleomycin-induced lung fibrosis, we evaluated whether a prototype CINOD compound, (S)-(5S)-5,6-bis(nitrooxy)hexyl)2-(6-methoxynaphthalen-2-yl)propanoate (NCX 466), may show an advantage over naproxen, its congener drug not releasing NO. Bleomycin (0.05 IU) was instilled intratracheally to C57BL/6 mice, which were then treated orally with vehicle, NCX 466 (1.9 or 19 mg/kg), or an equimolar dose of naproxen (1 or 10 mg/kg) once daily for 14 days. " 05/01/2012 - "Prevention of bleomycin-induced lung fibrosis in mice by a novel approach of parallel inhibition of cyclooxygenase and nitric-oxide donation using NCX 466, a prototype cyclooxygenase inhibitor and nitric-oxide donor."

Related Drugs and Biologics

1.	Nitric Oxide Donors
2.	Cyclooxygenase Inhibitors
3.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
4.	Nitric Oxide (Nitrogen Monoxide)
5.	Naproxen (Naprosyn)
6.	Collagen
7.	Bleomycin (Blenoxane)