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EDL-291

structure in first source

Also Known As:

6,7-dimethoxy-1-(4-(4-methoxypyridin-3-yl)benzyl)-1,2,3,4-tetrahydroisoquinoline dihydrochloride

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - EDL-291: 1

Experts

1.	Abner, Clint W: 1 article (06/2012)
2.	Freeman, Natalie E: 1 article (06/2012)
3.	Geisert, Eldon E: 1 article (06/2012)
4.	Miller, Duane D: 1 article (06/2012)
5.	Mitra, Suchareeta: 1 article (06/2012)
6.	Orr, William E: 1 article (06/2012)
7.	Patil, Renukadevi: 1 article (06/2012)
8.	Patil, Shivaputra A: 1 article (06/2012)
9.	Wang, Xiang-Di: 1 article (06/2012)
10.	Yates, Charles Ryan: 1 article (06/2012)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2012 - "In vivo, a low dosage of EDL-291 is sufficient and effective in reducing glioblastoma tumor size. "
2.	Glioblastoma (Glioblastoma Multiforme) 06/01/2012 - "The efficacy of EDL-291 was monitored in vivo using a rat glioblastoma model. " 06/01/2012 - "EDL-291 selectively induces cell death in rat and human glioblastoma cell lines by the induction of autophagy. " 06/01/2012 - "EDL-291 inhibits glioblastoma in vitro by destroying the mitochondria as shown with Mito Tracker Green FM. " 06/01/2012 - "Rat glioblastoma cells were transplanted into an intracranial rat model, followed by infusions of saline, a low dose of EDL-291 (20 mg/kg for the first half hour, followed by 40 mg/kg EDL-291 in saline for 4 h), or a high dose of EDL-291 (60 mg/kg for the first half hour, followed by 90 mg/kg EDL-291 for 4 h). " 06/01/2012 - "Dose-response curves were generated to determine the EC50 in rat and human glioblastoma cell lines by treatment with different dilutions of EDL-291. "

Related Drugs and Biologics

1.	Acridine Orange
2.	1,2,3,4-tetrahydroisoquinoline

Related Therapies and Procedures

1.	Aftercare (After-Treatment)