tocol

synthetic with antiproliferative and proapoptotic effects; structure in first source

Also Known As:

2-methyl-2-(4,8,12-trimethyltridecyl)-6-chromanol; 2H-1-Benzopyran-6-ol, 3,4-dihydro-2-methyl-2-(4,8,12-trimethyltridecyl)-

Networked: 7 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Vitamin E: 8680
        Tocopherols: 1861
        tocol: 7
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Vitamin E: 8680
        Tocopherols: 1861
        tocol: 7

Experts

1.	Newman, Victoria L: 2 articles (01/2016 - 11/2014)
2.	Romaine, Patricia L P: 2 articles (01/2016 - 11/2014)
3.	Singh, Vijay K: 2 articles (01/2016 - 11/2014)
4.	Astiazaran-García, Humberto: 1 article (05/2022)
5.	De la Rosa, Laura A: 1 article (05/2022)
6.	Olivas-Armendáriz, Imelda: 1 article (05/2022)
7.	Robles-Zepeda, Ramón E: 1 article (05/2022)
8.	Stevens-Barrón, Jazmín C: 1 article (05/2022)
9.	Wall-Medrano, Abraham: 1 article (05/2022)
10.	Álvarez-Parrilla, Emilio: 1 article (05/2022)

Related Diseases

1.	Central Nervous System Diseases (CNS Diseases) 02/28/2012 - "Tocol NLCs improved baicalein's stability and the ability of baicalein to penetrate the brain; thus, this is a promising drug-targeting system for the treatment of central nervous system disorders."
2.	Acute Radiation Syndrome 01/01/2016 - "This article reviews studies of progenitor mobilization with gamma-tocotrienol (GT3), a tocol under advanced development as a radiation countermeasure for acute radiation syndrome (ARS). " 11/01/2014 - "This article reviews studies in which CD2F1 mice were irradiated with sufficiently high doses to cause acute radiation syndrome symptoms and then administered (iv) progenitor-enriched whole blood or peripheral blood mononuclear cells from tocol- and AMD3100-injected donor mice (AMD3100 is a chemokine receptor antagonist used to improve the yield of mobilised progenitors). "
3.	Neoplasms (Cancer) 05/14/2022 - "In the present study, the antiproliferative activity of pure tocols and phenolic compounds, tocol- and phenolic-rich extracts (TRE and PRE, respectively) from tree nuts and the extracts combinations, was evaluated in four cancer (HeLa, MCF7, PC3, A549) and one control (ARPE) cell lines. " 05/14/2022 - "Synergistic Interactions between Tocol and Phenolic Extracts from Different Tree Nut Species against Human Cancer Cell Lines." 02/03/2022 - "In this study, a structurally enhanced camptothecin analog, SN22, reversibly coupled with a redox-silent tocol derivative (tocopheryl oxamate) to allow its optimally stable encapsulation and controlled release from PEGylated sub-100 nm nanoparticles (NP), exhibited strong NB cell growth inhibitory activity, translating into rapid regression and durably suppressed regrowth of orthotopic, MYCN-amplified NB tumors. "
4.	Cognitive Dysfunction 05/01/2012 - "40 healthy volunteers with no history of cognitive impairment, neurological impairment, or lower extremity surgery or injury within the previous 12 mo. Presynaptic and postsynaptic mechanisms were evaluated with a chronic stretching pro- tocol. "
5.	Sepsis (Septicemia) 11/01/2014 - "The findings suggest that the therapeutic performance (i.e., reduction in oxidative damage in tissues) of CUR can be enhanced by employing tocol acetate nanoemulsions (via improving pharmacokinetics and tissue distribution) as a platform for drug delivery in sepsis-induced organ injury."

Related Drugs and Biologics

1.	baicalein
2.	Chemokine Receptors
3.	Camptothecin
4.	plerixafor
5.	plastochromanol 8
6.	Acetates (Acetic Acid Esters)