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1- (5- ((2,4- difluorophenyl)thio)- 4- nitrothiophen- 2- yl)ethanone

a USP7 inhibitor; structure in first source

Also Known As:

P22077

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - 1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone: 9
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - 1-(5-((2,4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone: 9

Experts

1.	Gao, Feng-Hou: 2 articles (01/2021 - 10/2016)
2.	Wu, Ying-Li: 2 articles (01/2021 - 10/2016)
3.	Chen, Xiang: 1 article (10/2021)
4.	Kuang, Xinwei: 1 article (10/2021)
5.	Liang, Long: 1 article (10/2021)
6.	Liu, Hong: 1 article (10/2021)
7.	Liu, Jing: 1 article (10/2021)
8.	Su, Juan: 1 article (10/2021)
9.	Xiang, Minmin: 1 article (10/2021)
10.	Xie, Zuozhong: 1 article (10/2021)

Related Diseases

1.	Neuroblastoma 01/01/2020 - "As an inhibitor of USP7, P22077 has been used to study the roles of USP7 in inflammatory response and neuroblastoma growth. " 10/17/2013 - "USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis."
2.	Lung Injury 01/01/2020 - "In vivo study showed that P22077 could relieve inflammatory response and reduce the lung injury in C57BL/6 mice with LPS-induced endotoxemia. "
3.	Endotoxemia 01/01/2020 - "In vivo study showed that P22077 could relieve inflammatory response and reduce the lung injury in C57BL/6 mice with LPS-induced endotoxemia. "
4.	Neoplasms (Cancer) 01/01/2020 - "In a xenograft model, P22077 efficiently inhibited tumor growth. " 11/23/2011 - "Importantly, we characterized the small molecule PR-619 as a broad-range DUB inhibitor, and P22077 as a USP7 inhibitor with potential for further development as a chemotherapeutic agent in cancer therapy. "
5.	Melanoma (Melanoma, Malignant) 10/01/2021 - "Inhibition of ubiquitin-specific protease-7 by P22077 also inhibits melanoma tumour growth in vivo. " 10/01/2021 - "Further, pharmacological inhibition of ubiquitin-specific protease-7 by P22077 can effectively inhibit proliferation, and induce cell cycle arrest and apoptosis via ROS accumulation-induced DNA damage in melanoma cells. " 10/01/2021 - "We investigated the role and the inhibitor P22077 of ubiquitin-specific protease-7 in melanoma treatment. "

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Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)