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8-hydroxyefavirenz

Also Known As:

6-chloro-4-(cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one; 8-hydroxy-efavirenz; 8-hydroxy-efavirenz-glucuronide

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - Benzoxazines: 58
      - 8-hydroxyefavirenz: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzoxazines: 58
      - 8-hydroxyefavirenz: 4

Experts

1.	Pumuye, Paul: 2 articles (11/2021 - 10/2021)
2.	Tucci, Joseph: 2 articles (11/2021 - 10/2021)
3.	Barratt, Daniel Thomas: 1 article (11/2021)
4.	Bordin Andriguetti, Natália: 1 article (11/2021)
5.	Somogyi, Andrew Alexander: 1 article (11/2021)
6.	Van Schalkwyk, Helena Katherina: 1 article (11/2021)
7.	Andriguetti, Natália Bordin: 1 article (10/2021)
8.	Barratt, Daniel T: 1 article (10/2021)
9.	Somogyi, Andrew A: 1 article (10/2021)
10.	Anderson, Sean G: 1 article (02/2020)

Related Diseases

1.	Tuberculosis (Tuberculoses) 12/01/2016 - "We compared the pharmacokinetic (PK) exposure parameters of efavirenz (EFV) and its major inactive metabolite, 8-hydroxy-efavirenz (8-OH-EFV), in an open-label, single-sequence, and parallel design of HIV-infected and tuberculosis (TB)-HIV-coinfected Ethiopian patients in the HIV-TB Pharmagene study with 20 and 33 patients, respectively. "
2.	Acquired Immunodeficiency Syndrome (AIDS) 11/01/2021 - "We have conducted the first investigation of the impact of c.516G>T and patient demographics on plasma efavirenz (EFV) and 8-hydroxyefavirenz (8OH-EFV) concentrations, metabolic ratio (8OH-EFV/EFV) (MR), and their association with adverse effects, in PNG patients with HIV/AIDS. " 10/01/2021 - "Efavirenz and 8-hydroxyefavirenz concentrations in HIV/AIDS patient (n=5) plasma prepared from pre-treated (60°C for 1 h) whole blood varied from 517-8564 ng/mL and 131-813 ng/mL, respectively. "
3.	Infections 02/01/2020 - "We describe the neurologic phenotype in South African patients with predominant HIV-1 subtype C infection on ART and its association with neurocognitive impairment and efavirenz and 8-hydroxy-efavirenz concentrations. "

Related Drugs and Biologics

1.	efavirenz (Sustiva)