N- (2- (diethylamino)ethyl)- 2- methyl- 7- (1,2- dihydro- 5- fluoro- 2- oxo- 3H- indol- 3- ylidene)- 4,5,6,7- tetrahydro- 1H- indole- 3- carboxamide

a receptor tyrosine kinase inhibitor with antiangiogenic and antineoplastic activities; structure in first source

Also Known As:

N-(2-(diethylamino)ethyl)-2-methyl-7-(1,2-dihydro-5-fluoro-2-oxo-3H-indol-(Z)-3-ylidene)-4,5,6,7-tetrahydro-1H-indole-3-carboxamide; SIM 010603; SIM-010603; SIM010603; tafetinib

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lu, Guocai: 1 article (05/2012)
2.	Mao, Yu: 1 article (05/2012)
3.	Xia, Zhenna: 1 article (05/2012)
4.	Yuan, Bojun: 1 article (05/2012)
5.	Zhang, Xiaofang: 1 article (05/2012)
6.	Zhu, Lin: 1 article (05/2012)
7.	Zong, Ying: 1 article (05/2012)
8.	Jiang, Zhenzhou: 1 article (01/2012)
9.	Tang, Feng: 1 article (01/2012)
10.	Wang, Dongchun: 1 article (01/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "This study investigated the anti-angiogenic and anti-tumor effects of SIM010603. " 01/01/2012 - "These results support the clinical assessment of SIM010603 as a therapeutic agent for cancer." 01/01/2012 - "SIM010603 reduced tumor MVD in T241-VEGF-A tumor xenograft models and decreased positive signals of CD31, NG2 in MDA-MB-435, and LLC-SW-44 xenograft tumor models. " 01/01/2012 - "Although SIM010603 exhibited lower activity in regard to proliferation of NCI-H460, MDA-MB-435, and T241-VEGF-A cells (IC(50) > 1 μmol/l), SIM010603 inhibited tumor growth in these xenograft tumor growth models. " 01/01/2012 - "Effects of SIM010603 on tumor microvascular density (MVD), recruitment of pericytes, and pericyte encapsulation of tumor vessels were analyzed by immunofluorescent staining technique. "
2.	Corneal Neovascularization 01/01/2012 - "Moreover, SIM010603 inhibited endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis. "
3.	Bronchopneumonia 05/01/2012 - "The adverse effects of SIM010603 on rats and dogs mainly included gastrointestinal toxicity, skeletal toxicity, myelosuppression, thymus atrophy, bronchopneumonia, cardiovascular dysfunction, and pancreatic toxicity. "
4.	Atrophy 05/01/2012 - "The adverse effects of SIM010603 on rats and dogs mainly included gastrointestinal toxicity, skeletal toxicity, myelosuppression, thymus atrophy, bronchopneumonia, cardiovascular dysfunction, and pancreatic toxicity. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	tyrosine receptor (receptor, tyrosine)