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BAY 60-4552

a riociguat metabolite that activates soluble guanylate cyclase

Also Known As:

BAY-60-4552; BAY60-4552

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - BAY 60-4552: 3
  - Pyrimidines: 510
    - BAY 60-4552: 3

Experts

1.	Sandner, Peter: 2 articles (05/2013 - 11/2011)
2.	Albersen, Maarten: 1 article (05/2013)
3.	Linsen, Loes: 1 article (05/2013)
4.	Tinel, Hanna: 1 article (05/2013)
5.	Van Renterghem, Koenraad: 1 article (05/2013)
6.	Ancellin, Nicolas: 1 article (01/2012)
7.	Ballard, Victoria L T: 1 article (01/2012)
8.	Behm, David J: 1 article (01/2012)
9.	Bernard, Roberta E: 1 article (01/2012)
10.	Bouillot, Anne: 1 article (01/2012)

Related Diseases

1.	Stroke (Strokes) 01/01/2012 - "The cardiovascular effects of the NO-insensitive sGC activator GSK2181236A [a low, non-depressor dose, and a high dose which lowered mean arterial pressure (MAP) by 5-10 mmHg] and those of equi-efficacious doses of the NO-sensitive sGC stimulator BAY 60-4552 were assessed in (1) Sprague Dawley rats during coronary artery ischemia/reperfusion (I/R) and (2) spontaneously hypertensive stroke prone rats (SHR-SP) on a high salt/fat diet (HSFD). "
2.	Ischemia 01/01/2012 - "The cardiovascular effects of the NO-insensitive sGC activator GSK2181236A [a low, non-depressor dose, and a high dose which lowered mean arterial pressure (MAP) by 5-10 mmHg] and those of equi-efficacious doses of the NO-sensitive sGC stimulator BAY 60-4552 were assessed in (1) Sprague Dawley rats during coronary artery ischemia/reperfusion (I/R) and (2) spontaneously hypertensive stroke prone rats (SHR-SP) on a high salt/fat diet (HSFD). "
3.	Erectile Dysfunction 05/01/2013 - "Synergistic effects of BAY 60-4552 and vardenafil on relaxation of corpus cavernosum tissue of patients with erectile dysfunction and clinical phosphodiesterase type 5 inhibitor failure."
4.	Hypertension (High Blood Pressure) 01/01/2012 - "In summary, GSK2181236A and BAY 60-4552 provide partial benefit against hypertension-induced end-organ damage. "
5.	Cardiomegaly (Heart Hypertrophy) 01/01/2012 - "Conversely, the low dose of GSK2181236A, but not that of BAY 60-4552, attenuated the development of cardiac hypertrophy. "

Related Drugs and Biologics

1.	Vardenafil Dihydrochloride (Levitra)
2.	Phosphodiesterase 5 Inhibitors
3.	Salts
4.	Soluble Guanylyl Cyclase