HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

3- (4- chlorophenyl)adamantane- 1- carboxylic acid 3,4-dihydroxybenzylamide

inhibits both sphingosine kinases 1 and 2; structure in first source

Also Known As:

ABC 294735; ABC-294735; ABC294735

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97

Experts

1.	Beljanski, Vladimir: 1 article (12/2011)
2.	Knaak, Christian: 1 article (12/2011)
3.	Smith, Charles D: 1 article (12/2011)
4.	Zhuang, Yan: 1 article (12/2011)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2011 - "Oral administration of either ABC294640 or ABC294735 to mice led to a delay in tumor growth in both xenograft models without overt toxicity to the animals. "
2.	Carcinoma (Carcinomatosis) 12/01/2011 - "Therefore, we evaluated the effects of two SK inhibitors, ABC294640 (a SK2-specific inhibitor) and ABC294735 (a dual SK1/SK2 inhibitor), alone and in combination with sorafenib on human pancreatic adenocarcinoma (Bxpc-3) and kidney carcinoma (A-498) cells in vitro and in vivo. "
3.	Adenocarcinoma 12/01/2011 - "Therefore, we evaluated the effects of two SK inhibitors, ABC294640 (a SK2-specific inhibitor) and ABC294735 (a dual SK1/SK2 inhibitor), alone and in combination with sorafenib on human pancreatic adenocarcinoma (Bxpc-3) and kidney carcinoma (A-498) cells in vitro and in vivo. "

Related Drugs and Biologics

1.	Sorafenib (BAY 43-9006)
2.	3- (4- chlorophenyl)- adamantane- 1- carboxylic acid (pyridin-4-ylmethyl)amide

Related Therapies and Procedures

1.	Oral Administration