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7- (3,5- dihydroxy- 2- (3- hydroxy- 5- phenylpentyl)cyclopentyl)- 5- heptenoic acid 6-(nitrooxy)hexyl amide

a latanoprost prodrug and nitrix oxide donor; structure in first source

Also Known As:

NCX 139; NCX-139; NCX139

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Electrolytes: 16106
  - Ions: 7857
    - Anions: 3501
      - Nitrates: 6625
        7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoic acid 6-(nitrooxy)hexyl amide: 1
- Nitrogen Compounds: 67
  - Nitric Acid: 155
    - Nitrates: 6625
      - 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoic acid 6-(nitrooxy)hexyl amide: 1
Organic Chemicals: 133
- Nitrates: 6625
  - 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoic acid 6-(nitrooxy)hexyl amide: 1
Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Synthetic Prostaglandins: 823
        Synthetic Prostaglandins F: 2
        7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoic acid 6-(nitrooxy)hexyl amide: 1
Biological Factors: 2472
- Inflammation Mediators: 1113
  - Synthetic Prostaglandins: 823
    - Synthetic Prostaglandins F: 2
      - 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoic acid 6-(nitrooxy)hexyl amide: 1
  - Autacoids: 276
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Synthetic Prostaglandins: 823
        Synthetic Prostaglandins F: 2
        7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoic acid 6-(nitrooxy)hexyl amide: 1

Experts

1.	Batugo, M: 1 article (09/2011)
2.	Borghi, V: 1 article (09/2011)
3.	Brambilla, S: 1 article (09/2011)
4.	Carreiro, S T: 1 article (09/2011)
5.	Chiroli, V: 1 article (09/2011)
6.	Chong, W K M: 1 article (09/2011)
7.	Gale, D C: 1 article (09/2011)
8.	Guzzetta, M: 1 article (09/2011)
9.	Impagnatiello, F: 1 article (09/2011)
10.	Krauss, A H P: 1 article (09/2011)

Related Diseases

1.	Ocular Hypertension (Glaucoma, Suspect) 09/01/2011 - "The IOP lowering effects of NCX 139, a new chemical entity comprising latanoprost amide and a NO-donating moiety, were compared to those of the respective des-nitro analog in in vitro assays and in rabbit and dog models of ocular hypertension. "
2.	Glaucoma 09/01/2011 - "NCX 139, a compound targeting two different and important mechanisms, is endowed with ocular hypotensive effects more evident in hypertensive conditions which may be of interest in the search of more effective treatments for hypertensive glaucoma."

Related Drugs and Biologics

1.	Amides
2.	Latanoprost (Xalatan)