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2- (sec- butylthio)- 6- (1- (2,6- difluorophenyl)propyl)- 5- methylpyrimidin- 4(3H)- one

has antineoplastic activity; structure in first source

Also Known As:

SPV 122; SPV-122; SPV122

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - 2-(sec-butylthio)-6-(1-(2,6-difluorophenyl)propyl)-5-methylpyrimidin-4(3H)-one: 3

Experts

1.	Milite, Ciro: 3 articles (01/2020 - 08/2011)
2.	Sbardella, Gianluca: 3 articles (01/2020 - 08/2011)
3.	Castellano, Sabrina: 2 articles (01/2020 - 08/2011)
4.	Cirilli, Roberto: 2 articles (01/2020 - 08/2011)
5.	Lavia, Patrizia: 2 articles (01/2020 - 08/2011)
6.	Sciamanna, Ilaria: 2 articles (01/2020 - 08/2011)
7.	Serafino, Annalucia: 2 articles (01/2020 - 08/2011)
8.	Spadafora, Corrado: 2 articles (01/2020 - 08/2011)
9.	Ascierto, Paolo A: 1 article (01/2020)
10.	Baranzini, Mirko: 1 article (01/2020)

Related Diseases

1.	Neoplasms (Cancer) 08/25/2011 - "Among tested compounds, the most potent is 3g (SPV122), which also induces apoptosis in a cell-density-dependent manner and antagonizes tumor growth in animal models. " 01/01/2020 - "efavirenz (EFV) and SPV122.2, reduce proliferation and promote differentiation of cancer cells, concomitant with a global reprogramming of the transcription profile. "
2.	Melanoma (Melanoma, Malignant) 01/01/2020 - "In this short report we show that the non-nucleoside RTI, SPV122 in combination with MAPKi strongly inhibits BRAF-mutant melanoma cell growth, induces apoptosis, and delays the emergence of resistance to target therapy in vitro. "

Related Drugs and Biologics

1.	Nucleosides
2.	efavirenz (Sustiva)

Related Therapies and Procedures

1.	Therapeutics