Type 3 Congenital Generalized Lipodystrophy

Also Known As:

Lipodystrophy, Congenital Generalized, Type 3; Berardinelli-Seip Congenital Lipodystrophy, Type 3; Bscl3; Cgl3; Lipodystrophy, Berardinelli-Seip Congenital, Type 3

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - Inborn Errors Metabolism: 1162
    - Inborn Errors Lipid Metabolism
      - Congenital Generalized Lipodystrophy: 255
        Type 3 Congenital Generalized Lipodystrophy: 5
Skin and Connective Tissue Diseases
- Skin Diseases: 13127
  - Metabolic Skin Diseases: 1
    - Lipodystrophy: 2297
      - Congenital Generalized Lipodystrophy: 255
        Type 3 Congenital Generalized Lipodystrophy: 5
Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142

Related Diseases

1.	Congenital Generalized Lipodystrophy (Berardinelli-Seip Congenital Lipodystrophy)

Experts

1.	Aebi, Markus: 2 articles (08/2015 - 05/2008)
2.	Künzler, Markus: 2 articles (08/2015 - 05/2008)
3.	Cui, Lihua: 1 article (07/2019)
4.	Dai, Xide: 1 article (07/2019)
5.	Huang, Zhujian: 1 article (07/2019)
6.	Liu, Junhong: 1 article (07/2019)
7.	Wu, Siying: 1 article (07/2019)
8.	Ye, Jiaer: 1 article (07/2019)
9.	Zhang, Li: 1 article (07/2019)
10.	Bleuler-Martinez, Silvia: 1 article (08/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Type 3 Congenital Generalized Lipodystrophy:

1.	LectinsIBA 05/23/2008 - "Here we present a structural and biochemical analysis of one representative, the galectin-related lectin CGL3 found in the inky cap mushroom Coprinopsis cinerea. " 08/19/2015 - "The effect of Coprinopsis cinerea lectins - CCL2, CGL2, CGL3; Aleuria aurantia lectin - AAL; Marasmius oreades agglutinin - MOA; and Laccaria bicolor lectin - Lb-Tec2, on cultivated Haemonchus contortus larval stages was investigated using a larval development test (LDT). "
2.	Proteins (Proteins, Gene)FDA Link 05/27/1999 - "Conversely, c-Fos, the canonical dimerization partner of Jun proteins is expressed in substantial quantity in HeLa- and 'CGL3' cells, but it is completely absent in AP-1 complexes from non-tumorigenic '444' cells. " 05/23/2008 - "Structural basis for chitotetraose coordination by CGL3, a novel galectin-related protein from Coprinopsis cinerea."
3.	Caveolin 1IBA 09/15/2008 - "Mutations in three genes, 1-acylglycerol 3-phosphate-O-acyltransferase 2 (AGPAT2), Berardinelli Seip Congenital Lipodystrophy 2 (BSCL2), and Caveolin-1 (CAV1) are associated with the three subtypes of this disorder, CGL1, CGL2 and CGL3, respectively. "
4.	Galectins (Galectin)IBA 05/23/2008 - "A Trp residue strictly conserved among galectins is changed to an Arg in CGL3 (R81). " 05/23/2008 - "Here we present a structural and biochemical analysis of one representative, the galectin-related lectin CGL3 found in the inky cap mushroom Coprinopsis cinerea. " 05/23/2008 - "Structural basis for chitotetraose coordination by CGL3, a novel galectin-related protein from Coprinopsis cinerea."
5.	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 05/27/1999 - "By using non-tumorigenic HeLa-fibroblast hybrids ('444'), their tumorigenic segregants ('CGL3') as well as HPV 18 positive HeLa cells as a experimental model system, evidence is provided that AP-1 composition differs considerably between these cell lines. " 05/27/1999 - "Conversely, c-Fos, the canonical dimerization partner of Jun proteins is expressed in substantial quantity in HeLa- and 'CGL3' cells, but it is completely absent in AP-1 complexes from non-tumorigenic '444' cells. "
6.	Polysaccharides (Glycans)IBA 05/23/2008 - "Screening of a glycan array revealed that CGL3 displays preference for oligomers of beta1-4-linked N-acetyl-glucosamines (chitooligosaccharides) and GalNAc beta 1-4GlcNAc (LacdiNAc). "
7.	CarbohydratesIBA 05/23/2008 - "Structural information was used to alter the carbohydrate-binding specificity and substrate affinity of CGL3. "
8.	AgglutininsIBA 08/19/2015 - "The effect of Coprinopsis cinerea lectins - CCL2, CGL2, CGL3; Aleuria aurantia lectin - AAL; Marasmius oreades agglutinin - MOA; and Laccaria bicolor lectin - Lb-Tec2, on cultivated Haemonchus contortus larval stages was investigated using a larval development test (LDT). "
9.	N- acetylgalactosaminyl- 1- 4- N- acetylglucosamineIBA 05/23/2008 - "Screening of a glycan array revealed that CGL3 displays preference for oligomers of beta1-4-linked N-acetyl-glucosamines (chitooligosaccharides) and GalNAc beta 1-4GlcNAc (LacdiNAc). "
10.	chromium hexavalent ionIBA 07/01/2019 - "The best-performing rGO@LDO composite (i.e., CGL3) exhibited enhanced visible light-driven photocatalytic Cr(VI) reduction, which was about five times higher than those of ZnAlTi-LDO (without adding hole catcher). "