Calcific Pancreatitis

Chronic pancreatitis characterized by the presents of calcified structures ("stones") in the pancreatic ducts and acini. OMIM: 167800

Also Known As:

Pancreatitis, Calcific

Networked: 75 relevant articles (7 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Digestive System Diseases: 1042
- Pancreatic Diseases: 1635
  - Pancreatitis: 23128
    - Chronic Pancreatitis: 5967
      - Calcific Pancreatitis: 75
Signs and Symptoms Pathological Conditions
- Pathologic Processes: 10023
  - Disease Attributes: 18
    - Chronic Disease: 25762
      - Chronic Pancreatitis: 5967
        Calcific Pancreatitis: 75

Related Diseases

1.	Pain (Aches)
2.	Shock
3.	Pancreatitis
4.	Diabetes Mellitus
5.	Cholestasis

Experts

1.	Freeman, Martin L: 2 articles (10/2019 - 01/2005)
2.	Palanivelu, C: 2 articles (10/2019 - 01/2011)
3.	Jalaly, Niloofar Y: 2 articles (04/2018 - 09/2016)
4.	Lennon, Anne Marie: 2 articles (04/2018 - 09/2016)
5.	Makary, Martin A: 2 articles (04/2018 - 09/2016)
6.	Moran, Robert A: 2 articles (04/2018 - 09/2016)
7.	Singh, Vikesh K: 2 articles (04/2018 - 09/2016)
8.	Bhansali, Anil: 2 articles (11/2017 - 03/2004)
9.	Fogel, Evan L: 2 articles (04/2017 - 05/2012)
10.	Lehman, Glen A: 2 articles (04/2017 - 05/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Calcific Pancreatitis:

1.	AntioxidantsIBA 09/01/2016 - "In this randomized, double-blind, placebo-controlled trial, chronic calcific pancreatitis patients with pain recurrence following pancreatic ductal clearance of stones received either antioxidant-pregabalin combination or matching placebo for 2 months followed by open-label antioxidants for the next 4 months in both groups. " 09/01/2016 - "The aim of this study was to evaluate the effect of antioxidant-pregabalin combination on pain recurrence in patients with chronic calcific pancreatitis. " 09/01/2016 - "Antioxidant-pregabalin combination results in significant relief in pain recurrence after ductal clearance in narcotic naïve patients with chronic calcific pancreatitis."
2.	Pregabalin (Lyrica)FDA Link 09/01/2016 - "In this randomized, double-blind, placebo-controlled trial, chronic calcific pancreatitis patients with pain recurrence following pancreatic ductal clearance of stones received either antioxidant-pregabalin combination or matching placebo for 2 months followed by open-label antioxidants for the next 4 months in both groups. " 09/01/2016 - "The aim of this study was to evaluate the effect of antioxidant-pregabalin combination on pain recurrence in patients with chronic calcific pancreatitis. " 09/01/2016 - "Antioxidant-pregabalin combination results in significant relief in pain recurrence after ductal clearance in narcotic naïve patients with chronic calcific pancreatitis."
3.	Secretin FDA Link 05/01/2012 - "Secretin during ESWL appears to aid clearance of MPDS in chronic calcific pancreatitis. " 02/15/1975 - "The pancreatic function test with secretin and cholecystokinin-pancreozymin correctly diagnosed 4 patients with non-calcific pancreatitis in whom the ERPC was normal. " 01/01/1976 - "Pancreozymin-secretin test (PS test) and intestinal absorption tests were performed in 21 patients with chronic calcific pancreatitis and 32 patients with chronic noncalcific pancreatitis to evaluate exocrine functions of the pancreas. " 05/01/1981 - "Calcium, enzyme, and total protein secretion were measured in secretin stimulated pancreatic juice in health, "early" chronic pancreatitis, and in chronic calcific pancreatitis. "
4.	Glucose (Dextrose)FDA LinkGeneric 07/01/1975 - "Abnormal glucose tolerance occurred in 91% of patients with calcific pancreatitis and 70% of patients with noncalific AIP in our follow up of five to 12 years. " 10/01/2019 - "We observed more rapid decline in smokers (AUC C-peptide, P = 0.043) and patients with surgical drainage (AUC glucose, P = 0.001; ratio, P = 0.03) or with calcific pancreatitis (HbA1c, P = 0.003). " 01/01/1978 - "Jejunal perfusion studies were performed to assess water, electrolyte, d-xylose, and d-glucose transport in 16 patients with chronic calcific pancreatitis (eight with and eight without steatorrhoea) and in 10 control subjects. "
5.	Alkaline PhosphataseIBA 01/01/1976 - "This study characterizes a syndrome of partial common bile duct obstruction and marked elevation in serum alkaline phosphatase in 6 male alcoholic patients with calcific pancreatitis. " 04/01/1980 - "Incomplete common bile duct obstruction due to calcific pancreatitis with a markedly elevated alkaline phosphatase." 01/01/1976 - "Marked alkaline phosphatase elevation with partial common bile duct obstruction due to calcific pancreatitis." 01/01/1976 - "This study demonstrates that calcific pancreatitis may cause partial bile duct obstruction which differentially increases serum alkaline phosphatase without altering bilirubin or bromsulphthalein excretion." 05/01/1980 - "Marked elevation of transaminases and alkaline phosphatase during asymptomatic cholangitis associated with calcific pancreatitis-induced common bile duct stricture."
6.	Xylose (D-Xylose)FDA Link 01/01/1976 - "(2) D-xylose tolerance test was abnormally low in only 6% of chronic pancreatitis, but Schilling test was evaluated abnormally low in 29% of chronic pancreatitis (50% of calcific pancreatitis and 11% of noncalcific pancreatitis). " 01/01/1978 - "Jejunal perfusion studies were performed to assess water, electrolyte, d-xylose, and d-glucose transport in 16 patients with chronic calcific pancreatitis (eight with and eight without steatorrhoea) and in 10 control subjects. "
7.	ElectrolytesIBA 02/01/1978 - "Sweat electrolytes were carried out in 84 adult patients with calcific pancreatitis, 51 with noncalcific pancreatitis, and the results compared to 37 adult controls. " 01/01/1978 - "Jejunal perfusion studies were performed to assess water, electrolyte, d-xylose, and d-glucose transport in 16 patients with chronic calcific pancreatitis (eight with and eight without steatorrhoea) and in 10 control subjects. "
8.	ZincIBA 09/01/2011 - "Influence of copper, iron, zinc and fe (3) (+) haemoglobin levels on the etiopathogenesis of chronic calcific pancreatitis--a study in patients with pancreatitis."
9.	IronIBA 09/01/2011 - "Influence of copper, iron, zinc and fe (3) (+) haemoglobin levels on the etiopathogenesis of chronic calcific pancreatitis--a study in patients with pancreatitis."
10.	HLA Antigens (Human Leukocyte Antigens)IBA 03/01/1982 - "In view of a possible role of genetic factors in the etiology of chronic calcific pancreatitis, we undertook a study of the frequency of HLA antigens in this disease. "

Therapies and Procedures

1.	Lithotripsy (Extracorporeal Shockwave Lithotripsy) 01/01/2003 - "Endoscopic removal of pancreatic stones after extracorporeal lithotripsy has been shown to result in long-term improvement in clinical outcomes in patients with chronic calcific pancreatitis. " 01/01/2018 - "Finally, there has been accumulating evidence for the use of pancreatoscopy-guided lithotripsy for the management of painful chronic calcific pancreatitis. " 11/01/2013 - "Long-term results of extracorporeal shockwave lithotripsy (ESWL) for large pancreatic duct (PD) stones in patients with idiopathic calcific pancreatitis (CP) are scanty. " 11/01/2013 - "Long-term clinical outcomes of extracorporeal shockwave lithotripsy in painful chronic calcific pancreatitis." 12/01/2000 - "Prospective evaluation of morphology, function, and quality of life after extracorporeal shockwave lithotripsy and endoscopic treatment of chronic calcific pancreatitis."
2.	Pancreaticojejunostomy 12/23/2022 - "Total robotic lateral pancreaticojejunostomy and modified Frey's procedure for chronic calcific pancreatitis." 02/01/2022 - "Diabetes Status After Lateral Pancreaticojejunostomy and Frey's Procedure in Chronic Calcific Pancreatitis: An Observational Study." 10/01/2019 - "Laparoscopic longitudinal pancreatojejunostomy and modified Frey's operation for chronic calcific pancreatitis." 01/01/2011 - "We report in this paper the first laparoendoscopic single-site lateral pancreaticojejunostomy (LPJ) for chronic calcific pancreatitis with dilated pancreatic duct. " 10/01/2019 - "Laparoscopic surgical management of chronic calcific pancreatitis with longitudinal pancreatojejunostomy or modified Frey's procedure is feasible, safe and effective in selected patients for the relief of pain."
3.	Conservative Treatment 05/01/2016 - "The ESWL is an effective and safe management option in patients with chronic calcific pancreatitis patients with main pancreatic duct stone size greater than 5 mm who did not get adequate pain relief with conservative management."
4.	Therapeutics 04/01/2017 - "Conclusions In selected patients with obstructive chronic calcific pancreatitis, the DPD bypass may be considered as a rescue endoscopic therapy, potentially obviating the need for surgery when standard endoscopic methods and ESWL fail." 09/01/1994 - "The effect of oral dissolution therapy for pancreatic stones was evaluated in patients with chronic calcific pancreatitis. " 01/01/2019 - "Our study aimed to evaluate the effect of oral litholysis in patients with chronic calcific pancreatitis (CCP) unresponsive to or ineligible for extracorporeal shock wave lithotripsy (ESWL) and endoscopic therapy. " 01/01/2019 - "Oral Litholysis in Patients with Chronic Calcific Pancreatitis Unresponsive to or Ineligible for Extracorporeal Shock Wave Lithotripsy and Endoscopic Therapy." 02/01/2004 - "Endoscopic therapy with multiple plastic stents for benign biliary strictures due to chronic calcific pancreatitis: the good, the bad, and the ugly."
5.	Pain Management 05/01/2016 - "Studies involving ESWL in chronic calcific pancreatitis with main pancreatic duct stones greater than 5 mm and patients that failed conservative pain management were included. " 01/01/2018 - "Case Presentation: We report the case of an 18-year-old male, who underwent celiac plexus block for pain management of chronic calcific pancreatitis and presented with pain in the epigastric region and the right flank. "