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Type A2 Postaxial Polydactyly

Also Known As:

Polydactyly, Postaxial, Type A2; Papa2; Postaxial Polydactyly, Type A2

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Musculoskeletal Diseases: 719
- Musculoskeletal Abnormalities: 43
  - Congenital Limb Deformities: 8
    - Polydactyly: 308
      - Type A2 Postaxial Polydactyly: 7
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Congenital Abnormalities: 25723
  - Musculoskeletal Abnormalities: 43
    - Congenital Limb Deformities: 8
      - Polydactyly: 308
        Type A2 Postaxial Polydactyly: 7

Related Diseases

1.	Infections
2.	Tuberculosis (Tuberculoses)

Experts

1.	Besra, Gurdyal S: 2 articles (05/2019 - 02/2007)
2.	Bhatt, Apoorva: 2 articles (05/2019 - 02/2007)
3.	Chaudhary, Sarika: 1 article (05/2019)
4.	Jatana, Nidhi: 1 article (05/2019)
5.	Malik, Anchal: 1 article (05/2019)
6.	Pal, Ravikant: 1 article (05/2019)
7.	Panchal, Vipul: 1 article (05/2019)
8.	Rao, Vivek: 1 article (05/2019)
9.	Taneja, Bhupesh: 1 article (05/2019)
10.	Thukral, Lipi: 1 article (05/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Type A2 Postaxial Polydactyly:

1.	Proteins (Proteins, Gene)FDA Link 05/01/2019 - "This study demonstrates the importance of a critical structural residue in the papA2 protein of Mtb and helps establish a link between observed genomic alteration and its molecular consequence in the successful human pathogen Mtb. "
2.	isopropyl methylphosphonic acidIBA 07/01/2006 - "Mouse infection studies showed a significant decrease in tissue colonization by mutants with a disruption in the gcpE, pstA, kdpC, papA2, impA, umaA1, or fabG2_2 gene. "
3.	AcyltransferasesIBA 02/01/2007 - "tuberculosis pks clusters are associated with a single PAP-encoding gene, it was demonstrated that another open reading frame, Rv3820c (papA2), located 5.8 kb downstream of papA1 is also an acyltransferase gene involved in SL-I biosynthesis: deletion of papA2 abolished SL-I production. " 07/03/2007 - "PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1."
4.	Virulence Factors (Pathogenicity Factors)IBA 07/03/2007 - "PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1."
5.	ZincIBA 05/01/2019 - "The investigation of structure of Mtb PapA2 revealed a distinct nonribosomal peptide synthetase (NRPS) C domain conformation with an unconventional presence of a zinc binding motif. "
6.	Proline (L-Proline)FDA Link 05/01/2019 - "We have identified a distinct lineage specific mutation-G247C, translating into an alanine-proline conversion in the papA2 gene of Indo-oceanic lineage 1 (L1) Mtb strains, and restoration of cell wall sulfolipids by simple genetic complementation of papA2 from lineage 3 (L3) or from H37Rv (lineage 4-L4) attributed the loss of this glycolipid to this specific mutation in Indo-Oceanic L1 Mtb. "
7.	LipidsIBA 11/01/2015 - "The mutant showed reduced expression of mmpL8, mmpL10, stf0, pks2 and papA2 genes involved in transport and metabolism of lipids recognized to induce proinflammatory response; these lipids were found to be decreased in the mutant. "
8.	GlycolipidsIBA 05/01/2019 - "We have identified a distinct lineage specific mutation-G247C, translating into an alanine-proline conversion in the papA2 gene of Indo-oceanic lineage 1 (L1) Mtb strains, and restoration of cell wall sulfolipids by simple genetic complementation of papA2 from lineage 3 (L3) or from H37Rv (lineage 4-L4) attributed the loss of this glycolipid to this specific mutation in Indo-Oceanic L1 Mtb. "
9.	AntigensIBA 06/01/1999 - "The papillary antigens ('PapA') determined in these tests were designated PapAl (applying the monoclonal antibody PapX 5C10), PapA2 (applying the monoclonal antibody PapX 12F6), and PapA3 (applying the monoclonal antibody PapXI 3C7). "
10.	Monoclonal AntibodiesIBA 06/01/1999 - "The papillary antigens ('PapA') determined in these tests were designated PapAl (applying the monoclonal antibody PapX 5C10), PapA2 (applying the monoclonal antibody PapX 12F6), and PapA3 (applying the monoclonal antibody PapXI 3C7). "