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Abnormal Thyroid Hormone Metabolism

can be caused by mutation of the SECISBP2 gene

Also Known As:

Thyroid Hormone Metabolism, Abnormal

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Endocrine System Diseases: 968
- Thyroid Diseases: 6126
  - Abnormal Thyroid Hormone Metabolism: 10

Related Diseases

1.	Heart Failure
2.	Diabetic Nephropathies (Diabetic Nephropathy)
3.	Type 2 Diabetes Mellitus (MODY)

Experts

1.	Refetoff, Samuel: 2 articles (10/2021 - 01/2021)
2.	Dumitrescu, Alexandra M: 2 articles (01/2021 - 01/2018)
3.	Dumitrescu, Alexandra: 1 article (10/2021)
4.	Echegoyen, Francisco Barrera: 1 article (10/2021)
5.	Furman, Aryel: 1 article (10/2021)
6.	Hannoush, Zeina: 1 article (10/2021)
7.	Weiss, Roy E: 1 article (10/2021)
8.	Bianco, Antonio C: 1 article (01/2021)
9.	Fernandes, Gustavo W: 1 article (01/2021)
10.	França, Monica M: 1 article (01/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Abnormal Thyroid Hormone Metabolism:

1.	Selenoproteins (Selenoprotein)IBA 01/01/2018 - "SECISBP2 is an essential factor in selenoprotein synthesis, and its mutations result in a multiorgan syndrome, including abnormal thyroid hormone metabolism. " 11/30/2007 - "We hypothesize that the selective loss of a subset of selenoproteins, including some involved in thyroid hormone homeostasis, is responsible for the abnormal thyroid hormone metabolism previously observed in the affected individuals." 08/01/2011 - "Individuals with inherited defects in selenocysteine insertion sequence (SECIS)-binding protein 2 display a syndrome of selenoprotein-related defects including abnormal thyroid hormone metabolism, delayed bone maturation, and other more individual phenotypes. "
2.	Triiodothyronine (Liothyronine)FDA LinkGeneric 10/01/2021 - "In the context of L-T4 replacement, the decreased D1 activity results in abnormal thyroid hormone metabolism with decreased triiodothyronine (T3) generation from L-T4 and may result in decreased T3 bioavailability during critical stages of development." 01/01/2020 - "Critical Issues: Abnormal thyroid hormone metabolism in patients can be corrected by triiodothyronine (T3) treatment. " 07/01/1990 - "To determine the prevalence and significance of abnormal thyroid hormone metabolism in congestive heart failure, free thyroxine (T4) index, free triiodothyronine (T3) index, reverse T3 and thyrotropin levels were obtained in 84 hospitalized patients with chronic advanced heart failure. "
3.	Carrier Proteins (Binding Protein)IBA 12/01/2008 - "In humans, mutations in the SBP2-encoding gene Sec insertion sequence binding protein 2 (SECISBP2) that alter the amino acid sequence or cause splicing defects lead to abnormal thyroid hormone metabolism. " 08/01/2011 - "Individuals with inherited defects in selenocysteine insertion sequence (SECIS)-binding protein 2 display a syndrome of selenoprotein-related defects including abnormal thyroid hormone metabolism, delayed bone maturation, and other more individual phenotypes. " 11/30/2007 - "Altered RNA binding activity underlies abnormal thyroid hormone metabolism linked to a mutation in selenocysteine insertion sequence-binding protein 2."
4.	SelenocysteineIBA 08/01/2011 - "Individuals with inherited defects in selenocysteine insertion sequence (SECIS)-binding protein 2 display a syndrome of selenoprotein-related defects including abnormal thyroid hormone metabolism, delayed bone maturation, and other more individual phenotypes. " 11/30/2007 - "Altered RNA binding activity underlies abnormal thyroid hormone metabolism linked to a mutation in selenocysteine insertion sequence-binding protein 2."
5.	Thyroid HormonesIBA 02/01/2019 - "Although abnormal thyroid hormone metabolism is common in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN), the relationship between thyroid hormones and DN is unclear and has been ignored during clinical practice. " 11/30/2007 - "We hypothesize that the selective loss of a subset of selenoproteins, including some involved in thyroid hormone homeostasis, is responsible for the abnormal thyroid hormone metabolism previously observed in the affected individuals."
6.	Iodide Peroxidase (Deiodinase)IBA 01/01/2021 - "Human Type 1 Iodothyronine Deiodinase (DIO1) Mutations Cause Abnormal Thyroid Hormone Metabolism." 01/01/1993 - "Thus, selenium-deficient rats have low tissue deiodinase activities and abnormal thyroid hormone metabolism. "
7.	Thyroxine (Levothyroxine)FDA LinkGeneric 07/01/1990 - "To determine the prevalence and significance of abnormal thyroid hormone metabolism in congestive heart failure, free thyroxine (T4) index, free triiodothyronine (T3) index, reverse T3 and thyrotropin levels were obtained in 84 hospitalized patients with chronic advanced heart failure. "
8.	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 07/01/1990 - "To determine the prevalence and significance of abnormal thyroid hormone metabolism in congestive heart failure, free thyroxine (T4) index, free triiodothyronine (T3) index, reverse T3 and thyrotropin levels were obtained in 84 hospitalized patients with chronic advanced heart failure. "
9.	SeleniumIBA 01/01/1993 - "Thus, selenium-deficient rats have low tissue deiodinase activities and abnormal thyroid hormone metabolism. "
10.	RNA (Ribonucleic Acid)IBA 11/30/2007 - "Altered RNA binding activity underlies abnormal thyroid hormone metabolism linked to a mutation in selenocysteine insertion sequence-binding protein 2."