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2 Combined Hyperlipidemia

Also Known As:

Hyperlipidemia, Combined, 2; FCHL2; HYPLIP2; Hyperlipidemia, Familial Combined, 2

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hypertriglyceridemia
2.	Atherosclerosis
3.	Hypercholesterolemia

Experts

1.	Gargalovic, Peter: 2 articles (10/2007 - 10/2004)
2.	Lusis, Aldons J: 2 articles (10/2007 - 10/2004)
3.	Frants, Rune R: 1 article (10/2007)
4.	Havekes, Louis M: 1 article (10/2007)
5.	Hofker, Marten H: 1 article (10/2007)
6.	Moen, Corina J A: 1 article (10/2007)
7.	Rensen, Patrick C N: 1 article (10/2007)
8.	Tholens, Aart P: 1 article (10/2007)
9.	Voshol, Peter J: 1 article (10/2007)
10.	de Haan, Willeke: 1 article (10/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to 2 Combined Hyperlipidemia:

1.	Triglycerides (Triacylglycerol)IBA 10/01/2007 - "The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides." 10/01/2007 - "Hyplip2 mice show increased plasma levels of cholesterol and predominantly triglycerides (TGs) and are susceptible to diet-induced atherosclerosis. "
2.	Fatty Acids (Saturated Fatty Acids)IBA 10/01/2007 - "In Hyplip2 mice, the particles were cleared at a decreased rate (half-life of 25 +/- 6 vs. 11 +/- 2 min; P < 0.05) concomitant with a decreased uptake of emulsion TG-derived (3)H-labeled fatty acids by the liver and white adipose tissue. "
3.	EmulsionsIBA 10/01/2007 - "In Hyplip2 mice, the particles were cleared at a decreased rate (half-life of 25 +/- 6 vs. 11 +/- 2 min; P < 0.05) concomitant with a decreased uptake of emulsion TG-derived (3)H-labeled fatty acids by the liver and white adipose tissue. "
4.	Cholesterol Ester Transfer ProteinsIBA 06/01/2004 - "Two mouse models were tested: 1) primary hypercholesterolemia resulting from the LDL-receptor gene knockout, and 2) combined hyperlipidemia resulting from crosses of LDL-receptor knockout mice with transgenic mice overexpressing apolipo protein (apo) CIII and cholesteryl ester-transfer protein. "
5.	LDL Receptors (LDL Receptor)IBA 06/01/2004 - "Two mouse models were tested: 1) primary hypercholesterolemia resulting from the LDL-receptor gene knockout, and 2) combined hyperlipidemia resulting from crosses of LDL-receptor knockout mice with transgenic mice overexpressing apolipo protein (apo) CIII and cholesteryl ester-transfer protein. "
6.	Proteins (Proteins, Gene)FDA Link 06/01/2004 - "Two mouse models were tested: 1) primary hypercholesterolemia resulting from the LDL-receptor gene knockout, and 2) combined hyperlipidemia resulting from crosses of LDL-receptor knockout mice with transgenic mice overexpressing apolipo protein (apo) CIII and cholesteryl ester-transfer protein. "
7.	LipidsIBA 10/01/2004 - "With respect to atherosclerotic lesions and some lipid parameters, this chromosome 15 gene, designated Hyplip2, exhibited dominant inheritance. "
8.	CholesterolIBA 10/01/2007 - "Hyplip2 mice show increased plasma levels of cholesterol and predominantly triglycerides (TGs) and are susceptible to diet-induced atherosclerosis. "
9.	Bile Acids and Salts (Bile Acids)IBA 10/01/2004 - "Expression array analyses suggested that Hyplip2 may influence inflammatory and bile acid synthesis pathways. "