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7 Hereditary Prostate Cancer

Also Known As:

Prostate Cancer, Hereditary, 7; Prostate Cancer Aggressiveness

Networked: 164 relevant articles (5 outcomes, 22 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer)
2.	Neoplasms (Cancer)
3.	Mitochondrial Diseases (Mitochondrial Disease)
4.	Chronic Disease (Chronic Diseases)
5.	Obesity

Experts

1.	Mohler, James L: 20 articles (06/2022 - 08/2006)
2.	Bensen, Jeannette T: 17 articles (06/2022 - 08/2006)
3.	Fontham, Elizabeth T H: 16 articles (06/2022 - 08/2006)
4.	Su, L Joseph: 14 articles (06/2022 - 08/2006)
5.	Arab, Lenore: 13 articles (06/2022 - 05/2011)
6.	Steck, Susan E: 13 articles (06/2022 - 05/2011)
7.	Smith, Gary J: 6 articles (01/2021 - 08/2006)
8.	Catalona, William J: 6 articles (04/2016 - 03/2006)
9.	Graefen, Markus: 5 articles (07/2020 - 06/2011)
10.	Hube-Magg, Claudia: 5 articles (07/2020 - 05/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to 7 Hereditary Prostate Cancer:

1.	Vitamin D FDA LinkGeneric 01/01/2017 - "Re: Serum Vitamin D is Not Helpful for Predicting Prostate Cancer Aggressiveness Compared with the Prostate Health Index: C. " 09/01/2016 - "Serum Vitamin D is Not Helpful for Predicting Prostate Cancer Aggressiveness Compared with the Prostate Health Index." 10/01/2007 - "We found no evidence that the two associated VDR single-nucleotide polymorphisms were modified by age at diagnosis, prostate cancer aggressiveness, first-degree family history of prostate cancer, or vitamin D intake. "
2.	Biomarkers (Surrogate Marker)IBA 11/01/2020 - "Biomarkers that could facilitate risk stratification of prostate cancer aggressiveness at the time of diagnosis may help to guide clinical treatment decisions and reduce overtreatment. " 11/01/2020 - "Our study reports promising findings suggesting that copy number losses might play an important role in the establishment of novel biomarkers to predict prostate cancer aggressiveness at the time of diagnosis. " 01/01/2018 - "The results of our study identify CENPF overexpression as an important mechanism and a potential biomarker for prostate cancer aggressiveness." 04/20/2016 - "Serum 25-OH D may serve as a useful biomarker in prostate cancer aggressiveness, which deserves continued study." 09/29/2022 - "HSP27/Menin Expression as New Prognostic Serum Biomarkers of Prostate Cancer Aggressiveness Independent of PSA."
3.	AndrogensIBA 07/01/2010 - "Inherited variations in AR, ESR1, and ESR2 genes are not associated with prostate cancer aggressiveness or with efficacy of androgen deprivation therapy." 12/01/2011 - "Genetic variants of genes in hormone metabolic pathways may influence plasma androgen levels or prostate cancer aggressiveness. " 06/01/2008 - "Genetic polymorphism in EGF is associated with prostate cancer aggressiveness and progression-free interval in androgen blockade-treated patients." 10/01/2007 - "We investigated the change in dihydrotestosterone in the prostate during androgen deprivation therapy in connection with prostate cancer aggressiveness using the Gleason score. " 10/01/2007 - "The change in the dihydrotestosterone level in the prostate before and after androgen deprivation therapy in connection with prostate cancer aggressiveness using the Gleason score."
4.	Prostate-Specific Antigen (Semenogelase)IBA 06/01/2011 - "It is superior to total prostate specific antigen, prostate specific antigen density and %free prostate specific antigen in predicting initial biopsy outcome, and may be indicative of prostate cancer aggressiveness." 02/01/2007 - "There are limited published validating data on the association of prostate specific antigen density with the criteria for prostate cancer aggressiveness. " 02/01/2007 - "Prostate specific antigen density correlates with features of prostate cancer aggressiveness." 03/01/1997 - "To evaluate serial measurements of free and total prostate-specific antigen (PSA) as a predictor of prostate cancer aggressiveness. " 05/01/2009 - "We considered associations with other surrogate markers of prostate cancer aggressiveness, such as Gleason score, pathologic stage, prostate-specific antigen at diagnosis, and age at diagnosis. "
5.	protein C activator peptideIBA 06/01/2022 - "Recreational and occupational physical activity in relation to prostate cancer aggressiveness: the North Carolina-Louisiana Prostate Cancer Project (PCaP)." 01/01/2019 - "Data from the population-based, case-only North Carolina-Louisiana Prostate Cancer Project (PCaP) were used to examine the association between diet quality, measured by MED and DASH scores, and prostate cancer aggressiveness in 1899 African American (AA) and European American (EA) research subjects. " 08/01/2006 - "The North Carolina-Louisiana Prostate Cancer Project (PCaP) is a multidisciplinary study of social, individual, and tumor-level causes of racial differences in prostate cancer aggressiveness. " 11/01/2019 - "A five-microRNA model (pCaP) for predicting prostate cancer aggressiveness using cell-free urine." 01/01/2016 - "The purpose of this study was to determine the relationship between total antioxidant capacity (TAC) from diet and supplements and prostate cancer aggressiveness among 855 African Americans (AA) and 945 European Americans (EA) in the North Carolina-Louisiana Prostate Cancer Project (PCaP). "
6.	Cadherins (E-Cadherin)IBA 08/01/2015 - "This study aims to provide a comprehensive view of the role and regulation of cell-cell adhesion in prostate cancer aggressiveness by examining the functional implications of both E-cadherin and Desmoglein 2 (DSG2). " 07/01/2009 - "Further mechanistic studies indicated that Runx2 accelerated prostate cancer aggressiveness through promotion of cadherin switching, invasion toward collagen I, and Akt activation. "
7.	Proteins (Proteins, Gene)FDA Link 07/03/2017 - "Impact of a protein-based assay that predicts prostate cancer aggressiveness on urologists' recommendations for active treatment or active surveillance: a randomized clinical utility trial." 01/01/2015 - "An association between protein expression and the main clinicopathological factors involved in prostate cancer aggressiveness was identified. " 11/01/2014 - "In humans, high THOC1 protein immunostaining associates with prostate cancer aggressiveness and recurrence. " 09/09/2014 - "We developed a performance-based strategy to identify protein biomarkers predictive of prostate cancer aggressiveness and lethality regardless of biopsy-sampling variation. " 04/05/2014 - "Evaluation of protein biomarkers of prostate cancer aggressiveness."
8.	Androgen Receptors (Androgen Receptor)IBA 01/01/2021 - "Androgen receptor signaling is crucial to prostate cancer aggressiveness. " 01/31/2017 - "Differential expression of miR-34b and androgen receptor pathway regulate prostate cancer aggressiveness between African-Americans and Caucasians." 02/01/2015 - "Androgen receptor splice variants contribute to prostate cancer aggressiveness through induction of EMT and expression of stem cell marker genes." 01/01/2016 - "Trinucleotide repeat length in the first exon of the androgen receptor gene may be associated with prostate carcinogenesis and facilitate prediction of prostate cancer aggressiveness." 03/01/2023 - "In the present study, we investigated the role of paracrine interleukin-8 (IL-8) in the antagonistic expression of IL-8 and androgen receptor (AR), and the contribution of IL-8 to prostate cancer aggressiveness. "
9.	AdipokinesIBA 01/01/2014 - "Our study aimed at evaluating the correlation of periprostatic fat (PF) on magnatic resonance imaging (MRI) and adipocytokines with prostate cancer aggressiveness. " 01/01/2016 - "To evaluate the correlation between the level of adipocytokines expression in periprostatic adipose tissue and the prostate cancer aggressiveness. " 01/01/2016 - "Influence of adipocytokines in periprostatic adipose tissue on prostate cancer aggressiveness." 01/01/2014 - "Periprostatic adiposity not only affects prostate cancer aggressiveness, but also influences the secretion of adipocytokines. " 01/01/2014 - "Influence of adipocytokines and periprostatic adiposity measurement parameters on prostate cancer aggressiveness."
10.	Interleukin-8 (Interleukin 8)IBA 03/01/2023 - "Megakaryocyte-Derived IL-8 Acts as a Paracrine Factor for Prostate Cancer Aggressiveness through CXCR2 Activation and Antagonistic AR Downregulation." 01/01/2020 - "IMPLICATIONS: IL8 expression is repressed by AR and is associated with prostate cancer aggressiveness and AR loss in metastatic disease." 01/01/2014 - "Nonetheless, an elevated secretion of IL-8 from normal cultured epithelial cells was associated with prostate cancer aggressiveness (P=0.0005). " 01/01/2014 - "IL-8 secretion in primary cultures of prostate cells is associated with prostate cancer aggressiveness." 03/01/2023 - "In the present study, we investigated the role of paracrine interleukin-8 (IL-8) in the antagonistic expression of IL-8 and androgen receptor (AR), and the contribution of IL-8 to prostate cancer aggressiveness. "

Therapies and Procedures

1.	Therapeutics 06/01/2015 - "Prostate cancer aggressiveness and appropriate therapy are routinely determined following biopsy sampling. " 07/01/2010 - "Inherited variations in AR, ESR1, and ESR2 genes are not associated with prostate cancer aggressiveness or with efficacy of androgen deprivation therapy." 01/01/2019 - "SIGNIFICANCE: These findings show that a major regulator of mitochondrial metabolism controls polyamine synthesis and prostate cancer aggressiveness, with potential applications in therapy and identification of new biomarkers." 10/01/2007 - "We investigated the change in dihydrotestosterone in the prostate during androgen deprivation therapy in connection with prostate cancer aggressiveness using the Gleason score. " 10/01/2007 - "The change in the dihydrotestosterone level in the prostate before and after androgen deprivation therapy in connection with prostate cancer aggressiveness using the Gleason score."
2.	Prostatectomy (Retropubic Prostatectomy) 04/01/2022 - "The volume and thickness of preprostatic fat on MRIs are not associated with prostate cancer aggressiveness in men undergoing radical prostatectomy." 02/01/2021 - "Peri-prostatic adipose tissue measurements using MRI predict prostate cancer aggressiveness in men undergoing radical prostatectomy." 01/01/2017 - "Normalized periprostatic fat MRI measurements can predict prostate cancer aggressiveness in men undergoing radical prostatectomy for clinically localised disease." 01/01/2015 - "Impact of tertiary Gleason pattern 5 on prostate cancer aggressiveness: Lessons from a contemporary single institution radical prostatectomy series." 07/01/2013 - "However, the clinical significance of these SNPs on prostate cancer aggressiveness and prognosis after radical prostatectomy (RP) has not been determined. "
3.	Mediterranean Diet 01/01/2019 - "The aim of this study was to evaluate the relationship between the Mediterranean diet (MED) and Dietary Approaches to Stop Hypertension (DASH) diet scores and prostate cancer aggressiveness by race. "
4.	Dietary Approaches To Stop Hypertension 01/01/2019 - "The aim of this study was to evaluate the relationship between the Mediterranean diet (MED) and Dietary Approaches to Stop Hypertension (DASH) diet scores and prostate cancer aggressiveness by race. "
5.	Radiotherapy 11/01/2020 - "The relationship between pre-radiation therapy testosterone levels and prostate cancer aggressiveness." 11/01/2020 - "We investigated whether there is an association between testosterone levels and prostate cancer aggressiveness in patients treated with radiation therapy who underwent a prostatectomy or prostate radiotherapy (EBRT). "