Multiple Cutaneous and Mucosal Venous Malformations

Also Known As:

Venous Malformations, Multiple Cutaneous and Mucosal; Mucocutaneous Venous Malformations; Vmcm1

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Cardiovascular Diseases: 91362
- Vascular Diseases: 15138
  - Arteriovenous Malformations: 2540
    - Multiple Cutaneous and Mucosal Venous Malformations: 3
- Cardiovascular Abnormalities: 452
  - Vascular Malformations: 1439
    - Arteriovenous Malformations: 2540
      - Multiple Cutaneous and Mucosal Venous Malformations: 3
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Congenital Abnormalities: 25723
  - Cardiovascular Abnormalities: 452
    - Vascular Malformations: 1439
      - Arteriovenous Malformations: 2540
        Multiple Cutaneous and Mucosal Venous Malformations: 3

Related Diseases

1.	Glomus vagale tumors
2.	Central Nervous System Cavernous Hemangioma
3.	Retinal Telangiectasis
4.	Vascular Malformations
5.	CADASIL

Experts

1.	Vikkula, M: 1 article (08/2006)
2.	Wang, Qing K: 1 article (01/2005)
3.	Akarsu, A Nurten: 1 article (04/2002)
4.	Cil, Barbaros E: 1 article (04/2002)
5.	Er, Nuray: 1 article (04/2002)
6.	Erk, Yucel: 1 article (04/2002)
7.	Ruacan, Sevket: 1 article (04/2002)
8.	Vargel, Ibrahim: 1 article (04/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Multiple Cutaneous and Mucosal Venous Malformations:

1.	TIE-2 Receptor (Receptor, TIE 2)IBA 08/01/2006 - "However, due to detailed analysis inherited forms have been observed, which has led to identify mutations in three genes causing familial vascular malformations: in the angiopoietin receptor TIE2 in mucocutaneous venous malformations (VMCM), in glomulin in glomuvenous malformations (GVM) and in RASA1 in the newly recognized phenotype capillary malformation-arteriovenous malformation (CM-AVM). "
2.	AngiopoietinsIBA 08/01/2006 - "However, due to detailed analysis inherited forms have been observed, which has led to identify mutations in three genes causing familial vascular malformations: in the angiopoietin receptor TIE2 in mucocutaneous venous malformations (VMCM), in glomulin in glomuvenous malformations (GVM) and in RASA1 in the newly recognized phenotype capillary malformation-arteriovenous malformation (CM-AVM). "
3.	Vascular Endothelial Growth Factor Receptor-3 (Flt 4)IBA 01/01/2005 - "These genes include AGGF1 for Klippel-Trenaunay syndrome, RASA1 for capillary malformations, KRIT1, MGC4607, PDCD10 for cerebral cavernous malformations, glomulin for glomuvenous malformations, TIE2 for multiple cutaneous and mucosal venous malformations, VEGFR-3, FOXC2, NEMO, SOX18 for lymphedema or related syndromes, ENG, ACVRLK1, MADH4 for HHT or related syndromes, NDP for Coats' disease, Notch3 for CADASIL, and PTEN for Proteus Syndrome. "
4.	Activins (Activin)IBA 04/15/2002 - "Homozygosity mapping excluded the following loci and/or genes: multiple cutaneous venous malformation (VMCM1; gene, TIE2) on chromosome 9p21; venous malformation with glomus cells (VMGLOM) on chromosome 1p22-p21; hereditary hemorrhagic telangiectasia type 1 (HHT1; gene, endoglin) and type 2 (HHT2; gene, activin) on chromosomes 9q34.1 and 12q11-q14, respectively; and cerebral cavernous malformation type 1 (CCM1; gene, KRIT1), type 2 (CCM2), and type 3 (CCM3) on chromosomes 7q11.2-q21, 7p15-p13, and 3q35.2-q27, respectively. "
5.	EndoglinIBA 04/15/2002 - "Homozygosity mapping excluded the following loci and/or genes: multiple cutaneous venous malformation (VMCM1; gene, TIE2) on chromosome 9p21; venous malformation with glomus cells (VMGLOM) on chromosome 1p22-p21; hereditary hemorrhagic telangiectasia type 1 (HHT1; gene, endoglin) and type 2 (HHT2; gene, activin) on chromosomes 9q34.1 and 12q11-q14, respectively; and cerebral cavernous malformation type 1 (CCM1; gene, KRIT1), type 2 (CCM2), and type 3 (CCM3) on chromosomes 7q11.2-q21, 7p15-p13, and 3q35.2-q27, respectively. "