1 Noninsulin-Dependent Diabetes Mellitus

Also Known As:

Diabetes Mellitus, Noninsulin-Dependent, 1; NIDDM1; Noninsulin-Dependent Diabetes Mellitus 1

Networked: 10 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10142
  - Glucose Metabolism Disorders: 375
    - Diabetes Mellitus: 56563
      - Type 2 Diabetes Mellitus: 95492
        1 Noninsulin-Dependent Diabetes Mellitus: 10
Endocrine System Diseases: 968
- Diabetes Mellitus: 56563
  - Type 2 Diabetes Mellitus: 95492
    - 1 Noninsulin-Dependent Diabetes Mellitus: 10

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY)
2.	3 Noninsulin-Dependent Diabetes Mellitus
3.	2 Noninsulin-Dependent Diabetes Mellitus
4.	Genetic Predisposition to Disease (Genetic Predisposition)
5.	Weight Loss (Weight Reduction)

Experts

1.	Abid, M: 1 article (06/2008)
2.	Ayadi, H: 1 article (06/2008)
3.	Boudawara, M: 1 article (06/2008)
4.	Granier, C: 1 article (06/2008)
5.	Hamza, N: 1 article (06/2008)
6.	Jarraya, F: 1 article (06/2008)
7.	Kifagi, C: 1 article (06/2008)
8.	Makni, K: 1 article (06/2008)
9.	Mnif, F: 1 article (06/2008)
10.	Rebaï, A: 1 article (06/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to 1 Noninsulin-Dependent Diabetes Mellitus:

1.	Peptide Hydrolases (Proteases)FDA Link 06/01/2008 - "Genome-wide analyses of the genetic predisposition to type 2 diabetes mellitus (T2DM) in different isolates and populations have identified regions of interest called non insulin-dependent diabetes mellitus (NIDDM) 1, 2, 3 and 4. At the NIDDM1 locus (2q37.3), calpain-10 (CAPN10) encodes for a ubiquitously expressed protease implicated in the two fundamental pathophysiological aspects of T2DM. " 02/01/2004 - "There are association studies on genetic variation at CAPN10 in different human populations over a range of phenotypes related to type 2 diabetes, physiological studies on the biological functions of calpain proteases, and evolutionary studies on CAPN10 and the NIDDM1 region. "
2.	NucleotidesIBA 05/10/2002 - "To study the contribution of single nucleotide polymorphism-UCSNP44 at calpain-10 gene (CAPN-10) on NIDDM1 locus to type 2 diabetes mellitus (T2DM) in Chinese. "
3.	CalpainIBA 02/01/2004 - "There are association studies on genetic variation at CAPN10 in different human populations over a range of phenotypes related to type 2 diabetes, physiological studies on the biological functions of calpain proteases, and evolutionary studies on CAPN10 and the NIDDM1 region. "
4.	Glucose (Dextrose)FDA LinkGeneric 12/01/1999 - "Congenic strains were established for Niddm1, the major quantitative trait locus (QTL) for postprandial glucose levels, by transfer of GK alleles onto the genome of the normoglycemic F344 rat. " 10/01/1992 - "Whereas the first three subgroups did not differ among themselves, they had significantly lower glucose utilization than did the normotensive NIDDM1 patients without microalbuminuria and nondiabetic controls (P < 0.01). " 10/01/1992 - "Whole-body glucose utilization in NIDDM patients--NIDDM4 versus NIDDM3 versus NIDDM2 versus NIDDM1 versus controls--was: 1.86 +/- 0.31 versus 2.21 +/- 0.39 versus 2.01 +/- 0.40 versus 5.98 +/- 0.77 versus 5.52 +/- 0.92 mg/kg/min (mean +/- SE). " 05/10/2002 - "[The UCSNP44 variation of calpain 10 gene on NIDDM1 locus and its impact on plasma glucose levels in type 2 diabetic patients]."
5.	calpain 10IBA 06/01/2002 - "However, only NIDDM1 has been mapped to a single gene, and that gene (calpain 10) appears to have a major role only in selected populations. " 02/01/2001 - "The responsible gene for NIDDM1 was recently identified to be Calpain 10, and SNP43 in this gene could explain all of the evidence for linkage in Mexican American type 2 diabetes." 05/10/2002 - "[The UCSNP44 variation of calpain 10 gene on NIDDM1 locus and its impact on plasma glucose levels in type 2 diabetic patients]."
6.	Insulin (Novolin)FDA Link 05/01/1988 - "We conclude that after weight loss in noninsulin-dependent diabetes mellitus, 1) insulin secretion is decreased in the basal state but increased after stimulation; 2) changes in insulin secretion are reflected by peripheral levels of C-peptide but not insulin, due in part to enhanced hepatic insulin extraction; and 3) at matched levels of hyperglycemia insulin secretion is markedly increased and similar to that in obese nondiabetic subjects studied at euglycemia."
7.	C-PeptideIBA 05/01/1988 - "We conclude that after weight loss in noninsulin-dependent diabetes mellitus, 1) insulin secretion is decreased in the basal state but increased after stimulation; 2) changes in insulin secretion are reflected by peripheral levels of C-peptide but not insulin, due in part to enhanced hepatic insulin extraction; and 3) at matched levels of hyperglycemia insulin secretion is markedly increased and similar to that in obese nondiabetic subjects studied at euglycemia."
8.	Aromatase (CYP19)IBA 02/01/1999 - "Using this method, we show that the interaction of genes on chromosomes 2 (NIDDM1) and 15 (near CYP19) makes a contribution to susceptibility to type 2 diabetes in Mexican Americans from Starr County, Texas."
9.	AlbuminsIBA 03/01/1994 - "These subjects were divided into four groups on the basis of BP levels and albumin excretion rate (AER): 28 normotensive normoalbuminuric (NIDDM1), 19 hypertensive normoalbuminuric (NIDDM2), 15 normotensive microalbuminuric (NIDDM3), and 13 hypertensive microalbuminuric patients (NIDDM4). "