Heparin Cofactor II Deficiency

mutation in HCF2

Also Known As:

Hcf II Deficiency; Thrombophilia, Susceptibility to, due to Heparin Cofactor Ii Deficiency

Networked: 17 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Activated Protein C Resistance (APC Resistance)
2.	Protein S Deficiency (Deficiency, Protein S)
3.	Protein C Deficiency
4.	Hypoalbuminemia
5.	Antithrombin III Deficiency

Experts

1.	Bick, Rodger L: 1 article (01/2005)
2.	Hoppensteadt, Debra: 1 article (01/2005)
3.	Matsuo, Takefumi: 1 article (05/2002)
4.	Korzets, Z: 1 article (06/2000)
5.	Lehmann, J: 1 article (06/2000)
6.	Witz, M: 1 article (06/2000)
7.	Hamasaki, S: 1 article (04/2000)
8.	Kondo, S: 1 article (04/2000)
9.	Motomura, M: 1 article (04/2000)
10.	Nakane, S: 1 article (04/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Heparin Cofactor II Deficiency:

1.	factor V LeidenIBA 02/01/2000 - "No activated protein C resistance, elevated factor VIII level, factor V Leiden, PT 20210 A allele or heparin cofactor II deficiency was found in the present study. " 01/01/2005 - "The remainder of the patients had a thrombophilia as follows: 195 (60%) had antiphospholipid syndrome, 64 (20%) had Sticky Platelet Syndrome, 38 (12%) had MTHFR mutation, 23 (7.1%) had PAI-1 polymorphism, 12 (3.7%) had Protein S deficiency, 12 (3.7%) had Factor V Leiden, 3 (1%), had AT deficiency, 3 (1%) had Heparin-Cofactor II deficiency, 3 (1%) had TPA deficiency, and 6 (2%) had Protein C deficiency. "
2.	Factor VIII (Coagulation Factor VIII)IBA 02/01/2000 - "No activated protein C resistance, elevated factor VIII level, factor V Leiden, PT 20210 A allele or heparin cofactor II deficiency was found in the present study. "
3.	Heparin Cofactor IIIBA 02/01/1996 - "Molecular and cellular basis for type I heparin cofactor II deficiency (heparin cofactor II Awaji)." 10/01/1985 - "Methodology and clinical significance of heparin cofactor II. Probable heparin cofactor II deficiency in a patient with cerebrovascular thrombosis." 05/01/2002 - "HEPARIN COFACTOR II DEFICIENCY: A patient with congenital heparin cofactor II(HCII) deficiency was found in clue to four episodes of repeated restenosis under heparin-anticoagulated coronary angioplasty. " 04/01/2000 - "Heparin cofactor II (HC II) activity was decreased (44%) with normal HC II antigen (79%) and so she was diagnosed as heparin cofactor II deficiency type II (heparin cofactor II abnormality). "
4.	Protein SIBA 03/01/1998 - "More recently, increased prevalence of protein S and heparin cofactor II deficiency, two physiological coagulation inhibitors were demonstrated in HIV-infected patients. " 06/01/2000 - "Apart from thrombocytopenia, these have included a prolonged APTT due to the presence of lupus anticoagulant, an increased prevalence of protein S and heparin cofactor II deficiency, and hypoalbuminemia-related fibrin polymerization defects (Toulon P. " 10/01/1991 - " the congenital defects involved were 3 probable heterozygous true deficiencies of antithrombin III (low ATIII antigen and activity); a decreased protein C antigen to factor X antigen ratio; a heparin cofactor II deficiency; and a type I protein S deficiency (low free protein S, with normal total protein S and normal levels of C4B-bp.) While 5 of these 6 women had family histories of thromboembolic disease, the drug was prescribed without knowing that they were heterozygous for a coagulation inhibitor deficiency. "
5.	AntithrombinsIBA 04/01/1990 - "Laboratory diagnosis of antithrombin and heparin cofactor II deficiency." 03/01/1997 - "Ten patients (0.47%) had antithrombin deficiency, 68 (3.19%) protein C deficiency, 155 (7.27%) protein S deficiency, 16 (0.75%) plasminogen deficiency, 8 (0.38%) heparin cofactor-II deficiency and 1 had dysfibrinogenemia. " 01/01/1997 - "For coronary artery disease in patients with deficiency of antithrombin activities attributable to either antithrombin III or heparin cofactor II deficiency, argatroban is effective as an anticoagulant. "
6.	Antithrombin IIIIBA 06/01/1992 - "Heparin cofactor II deficiency in the elderly: comparison with antithrombin III." 01/01/1997 - "For coronary artery disease in patients with deficiency of antithrombin activities attributable to either antithrombin III or heparin cofactor II deficiency, argatroban is effective as an anticoagulant. " 10/01/1991 - " the congenital defects involved were 3 probable heterozygous true deficiencies of antithrombin III (low ATIII antigen and activity); a decreased protein C antigen to factor X antigen ratio; a heparin cofactor II deficiency; and a type I protein S deficiency (low free protein S, with normal total protein S and normal levels of C4B-bp.) While 5 of these 6 women had family histories of thromboembolic disease, the drug was prescribed without knowing that they were heterozygous for a coagulation inhibitor deficiency. "
7.	PlasminogenIBA 10/01/1993 - "There were 17 cases of protein C deficiency (PC), 15 protein S deficiency (PS), 10 antithrombin III deficiency (ATIII), 3 dyfibrinogenemia, 2 heparin cofactor II deficiency, and 2 plasminogen defects. " 03/01/1997 - "Ten patients (0.47%) had antithrombin deficiency, 68 (3.19%) protein C deficiency, 155 (7.27%) protein S deficiency, 16 (0.75%) plasminogen deficiency, 8 (0.38%) heparin cofactor-II deficiency and 1 had dysfibrinogenemia. "
8.	AntigensIBA 04/01/2000 - "Heparin cofactor II (HC II) activity was decreased (44%) with normal HC II antigen (79%) and so she was diagnosed as heparin cofactor II deficiency type II (heparin cofactor II abnormality). " 10/01/1991 - " the congenital defects involved were 3 probable heterozygous true deficiencies of antithrombin III (low ATIII antigen and activity); a decreased protein C antigen to factor X antigen ratio; a heparin cofactor II deficiency; and a type I protein S deficiency (low free protein S, with normal total protein S and normal levels of C4B-bp.) While 5 of these 6 women had family histories of thromboembolic disease, the drug was prescribed without knowing that they were heterozygous for a coagulation inhibitor deficiency. "
9.	Plasminogen Activator Inhibitor 1IBA 01/01/2005 - "The remainder of the patients had a thrombophilia as follows: 195 (60%) had antiphospholipid syndrome, 64 (20%) had Sticky Platelet Syndrome, 38 (12%) had MTHFR mutation, 23 (7.1%) had PAI-1 polymorphism, 12 (3.7%) had Protein S deficiency, 12 (3.7%) had Factor V Leiden, 3 (1%), had AT deficiency, 3 (1%) had Heparin-Cofactor II deficiency, 3 (1%) had TPA deficiency, and 6 (2%) had Protein C deficiency. "
10.	Lupus Coagulation Inhibitor (Lupus Anticoagulant)IBA 06/01/2000 - "Apart from thrombocytopenia, these have included a prolonged APTT due to the presence of lupus anticoagulant, an increased prevalence of protein S and heparin cofactor II deficiency, and hypoalbuminemia-related fibrin polymerization defects (Toulon P. "

Therapies and Procedures

1.	Liver Transplantation 08/03/1992 - "Lack of correction of acquired heparin cofactor II deficiency in patients with liver failure after successful orthotopic liver transplantation."