Ovarian Teratoma

Usually benign, non-seminomatous GERM CELL TUMORS that originate from the ovary and are characterized by the presence of tissues which correspond to the different GERM LAYERS. Mature teratomas are composed of well differentiated, adult-type tissues. Immature teratomas are composed of immature, fetal type-tissues. They arise through failure of extrusion of the second POLAR BODY or refusion of it with the ovum. OMIM: 166950

Also Known As:

Networked: 296 relevant articles (11 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Lymphadenopathy
3.	Autoimmune Diseases of the Nervous System
4.	Neoplasm Metastasis (Metastasis)
5.	Wounds and Injuries (Trauma)

Experts

1.	Dalmau, Josep: 6 articles (01/2020 - 01/2007)
2.	Takahashi, Yukitoshi: 6 articles (05/2017 - 01/2007)
3.	Iizuka, Takahiro: 4 articles (03/2018 - 09/2008)
4.	Tanaka, Keiko: 4 articles (05/2017 - 01/2010)
5.	Tachibana, Naoko: 4 articles (01/2014 - 01/2010)
6.	Ren, Haitao: 3 articles (11/2019 - 04/2014)
7.	Kamei, Satoshi: 3 articles (01/2012 - 11/2008)
8.	Gillis, David: 2 articles (11/2022 - 12/2018)
9.	Arsalane, Abdelilah: 2 articles (08/2022 - 07/2021)
10.	El Hanna, Johnny: 2 articles (08/2022 - 07/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ovarian Teratoma:

1.	AntibodiesIBA 12/01/2019 - "Complementary studies disclosed that the three patients had ovarian teratoma as well as abnormal EEG, and CSF antibodies against NMDAR. " 01/01/2023 - "The second patient had no detectable antibodies in serum or CSF; however, she had an underlying ovarian teratoma. " 01/01/2022 - "Further investigation showed presence of bilateral ovarian teratoma and anti-NMDAR antibodies in her serum and cerebrospinal fluid. " 01/01/2022 - "Here, we present a pediatric patient who developed symptoms consistent with area postrema syndrome with positive anti-aquaporin-4 (AQP4) antibodies who was also found to have an ovarian teratoma. " 01/01/2019 - "Up to 50% of the affected young female patients have germ-cells tumours as ovarian teratoma, making it essential to establish an early diagnosis through detection of specific antibodies in serum and cerebrospinal fluid (CSF). "
2.	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 08/01/2012 - "Total-body 18F-FDG PET/CT studies helped to differentiate benign from malignant ovarian teratoma, as well as abdominal lymphadenopathy, subsequently confirmed by histopathology. " 08/01/2012 - "Assessment of ovarian teratoma and lymphadenopathy by 18F-FDG PET/CT."
3.	AntigensIBA 01/01/2022 - "We describe a 27-year-old woman with the delayed onset of OMS one month after resection of ovarian teratoma, likely due to immune trigger from antigen exposure at the time of resection. " 10/01/1995 - "To identify the cellular composition of the ovarian teratoma and of the omental implants, immunostainings were performed using antibodies against glial and neuronal antigens as well as against determinants of hematopoietic cells. "
4.	Antiviral Agents (Antivirals)IBA 01/01/2021 - "Our findings suggested that the combination of multiple therapies including antiviral, immunotherapy, and resection of tumors were appropriate and improved the prognosis, when HHV-7 infection and ovarian teratoma were concomitant with multiple anti-neuronal antibodies of autoimmune encephalitis."
5.	camrelizumabIBA 07/01/2021 - "Here we reported a patient who suffered malignant transformation of ovarian teratoma and responded well to camrelizumab, an anti-PD-1 inhibitor."
6.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 08/04/2019 - "The mass was surgically removed and histology revealed benign ovarian teratoma with NMDA receptors. " 01/01/2019 - "Ovarian teratoma commonly coexists, particularly among patients with accompanying N-methyl-D-aspartate receptor or aquaporin-4 autoimmunity. " 09/01/2015 - "Neither patient with anti-NMDA receptor antibody positivity had evidence of an ovarian teratoma. " 10/29/2023 - "In young women with anti-N-methyl-D-aspartate receptor (anti-NMDAR) autoimmune encephalitis (AE), co-occurrence with ovarian teratoma is common. " 07/11/2023 - "Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune antibody encephalitis, commonly affecting young women with comorbid ovarian teratoma. "
7.	N-Methylaspartate (NMDA)IBA 10/31/2018 - "Herein, to the best of our knowledge, in Saudi Arabia, we report the first ever case of mature ovarian teratoma-associated anti-NMDA receptor encephalitis in a 21-year-old Saudi woman who presented to clinical attention with a nine-day history of neuropsychiatric symptoms preceded by a two-day flu-like illness. " 01/01/2023 - "Anti-NMDA encephalitis caused by ovarian teratoma is mostly a non-specific clinical manifestation of neurological and mental abnormalities, which can be easily misdiagnosed and delayed, and doctors should fully recognise the disease, early diagnosis, and timely surgical intervention to improve the prognosis of patients." 11/01/2022 - "In this cohort, the number of cases of anti-NMDA-R encephalitis triggered by HSVE is comparable to those triggered by ovarian teratoma. " 11/01/2022 - "Three cases of anti-NMDA-R encephalitis were triggered by prior HSVE, five cases were associated with ovarian teratoma and 23 cases had no identifiable trigger. " 12/01/2021 - "A Bolt from the Blue: A case of NMDA Encephalitis with a Small Ovarian Teratoma, and review."
8.	Proteins (Proteins, Gene)FDA Link 02/01/2011 - "Proteomic study revealed that 17 proteins had the expression changes over eightfold in ovarian teratoma MSCLCs compared with normal control. " 01/01/2016 - "They can reveal ovarian teratoma which express neuroendocrine proteins, or contain mature or immature neural tissue inducing an autoimmune response. " 07/11/2023 - " our knowledge, this is the first illustrated case in the literature of a pregnant woman presenting with concurrent autoimmune NMDAR and anti-glial gibrillary acidic protein(GFAP) antibody encephalitis in the setting of an ovarian teratoma. " 11/01/2022 - "We report a sebaceous carcinoma arising in an ovarian teratoma in a 49-yr old (the 14th case reported in the literature) which exhibited loss of expression of MMR proteins MSH2 and MSH6. "
9.	RNA (Ribonucleic Acid)IBA 01/01/2020 - "To dissect the disease heterogeneity and identify the underlying cellular and molecular events related to metastasis of immature ovarian teratoma in children, single-cell RNA sequencing was performed for a 2-year-old patient with liver metastases from immature ovarian teratoma. " 12/01/2022 - "In this study, we report a very rare case of a female with anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma that would be triggered by BNT162b2 m-RNA COVID-19 vaccination." 01/01/2022 - "Consistent with this immunoglobulin class bias, ovarian teratoma samples showed intratumoral production of both NR1-IgG and NR1-IgA and, by single cell RNA sequencing, contained expanded highly-mutated IgA clones with an ovarian teratoma-restricted B cell population. "
10.	Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric 01/01/1983 - "A benign ovarian teratoma and an intraductal mammary carcinoma were found in an adult rhesus monkey that had been used in reproductive studies and received human luteinizing hormone, follicle-stimulating hormone, and human chorionic gonadotropin." 04/01/1993 - "These neoplasms differed from the usual immature ovarian teratoma as they contained no neuroectodermal components and had high alpha-fetoprotein and low human chorionic gonadotropin levels as their serum markers despite the absence of other concomitant germ cell tumors. "

Therapies and Procedures

1.	Immunotherapy 04/02/2019 - "We report a 14-year-old girl with paraneoplastic OMAS in association with an ovarian teratoma who improved completely following resection of tumour as well as immunotherapy and review the literature briefly." 08/08/2016 - "After resection of the underlying ovarian teratoma and with multimodal immunotherapy the patient substantially improved reaching a modified Rankin Scale score of 2 after 3 months. " 10/01/2021 - "However, upon diagnosis, all patients underwent surgical removal of the ovarian teratoma followed by intensive immunotherapy. " 01/01/2018 - "Around 20% of patients have an underlying ovarian teratoma, and the condition responds to early immunotherapies and ovarian teratoma removal. " 07/01/2021 - "Malignant transformation of ovarian teratoma responded well to immunotherapy after failed chemotherapy: a case report."
2.	Ovariectomy (Oophorectomy) 01/01/2022 - "A Case of Prepubertal Ovarian Tissue Cryopreservation in Metachronous Bilateral Mature Ovarian Teratoma Requiring Bilateral Oophorectomy." 01/01/2021 - "Ovarian teratoma was considered after pelvic MRI, which was then pathologically confirmed after laparoscopic ovariectomy. " 11/30/2018 - "To the best of the authors' knowledge, this is the first reported case of an ovarian teratoma removed by laparoscopic ovariectomy in a dog by using a multiport laparoscopic ovariectomy technique." 11/30/2018 - "Ovarian teratoma removed by laparoscopic ovariectomy in a dog." 10/24/2016 - "Multiple imaging investigations showed no evidence of an ovarian teratoma; she had a bilateral oophorectomy 29 days after admission. "
3.	Therapeutics 11/01/2019 - "However, the optimal treatment remains unknown, and strategies used for the diagnosis and therapy, including surgical intervention of ovarian teratoma, are debatable. " 10/01/2017 - "Immature Ovarian Teratoma: When to Give Adjuvant Therapy?" 06/01/2011 - "Adequate evaluation prior to surgery in suspected ovarian teratoma with malignant transformation is critical to determine extent of surgery and adjuvant therapy. " 02/01/2006 - "In this report we describe diagnosis and therapy of 26 years old primary gravida with 7 cm ovarian teratoma. " 10/01/2011 - "Incidental finding of ovarian teratoma on post-therapy scan for papillary thyroid cancer and impact of SPECT/CT imaging."
4.	Drug Therapy (Chemotherapy) 09/01/2019 - "She had a history of surgery and chemotherapy for an immature ovarian teratoma 33 years prior to presentation. " 09/01/1983 - "Unintentionally, a mature ovarian teratoma was treated by cytotoxic chemotherapy from an early stage. " 02/01/1983 - "[2 cases of solid ovarian teratoma with resistance to chemotherapy]." 07/01/2021 - "Malignant transformation of ovarian teratoma responded well to immunotherapy after failed chemotherapy: a case report." 10/29/2023 - "This case highlights the importance of a high index of suspicion for concurrent AE in the presence of ovarian teratoma, particularly IT, and the crucial role of concurrent administration of immunotherapy and chemotherapy following tumour resection in impacting prognosis."
5.	Laparotomy 12/01/2004 - "Laparoscopy is superior to laparotomy in the treatment of mature ovarian teratoma. " 09/01/2022 - "Challenges in Anaesthesia Management of a 15-Year-Old Female With Ovarian Teratoma for Exploratory Laparotomy: A Case Report." 01/01/2020 - "The histopathological exam, after a laparotomy, showed a mature ovarian teratoma." 08/01/2012 - "A 43-year-old female patient with SPMA was scheduled to undergo laparotomy for ovarian teratoma. " 01/01/2020 - "We revealed 7 major branches of research within the topic of ovarian teratoma in pediatric population: recurrence rate/relapse and follow-up strategy, malignant potential, prognostic factors, use of sparing surgery, differences between the use of laparoscopy and laparotomy, use of chemotherapy, and additional examinations to test the character of the lesion (immature vs. mature). "