Familial Polythelia

An autosomal dominant congenital abnormality characterized by supernumerary nipples and/or accessory breasts in females. OMIM: 163700

Also Known As:

Polythelia, Familial; Accessory Nipples; Nipples, Supernumerary; Polymastia

Networked: 24 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Skin and Connective Tissue Diseases
- Skin Diseases: 13127
  - Breast Diseases: 1550
    - Familial Polythelia: 24
Body Regions
- Breast
  - Nipples
    - Familial Polythelia: 24

Related Diseases

1.	Glioma (Gliomas)
2.	Thrombophlebitis
3.	Hypospadias
4.	Epilepsy (Aura)
5.	Craniosynostoses (Craniosynostosis)

Experts

1.	Apel, Miriam Anders: 2 articles (10/2009 - 02/2009)
2.	Battastini, Ana Maria Oliveira: 2 articles (10/2009 - 02/2009)
3.	Braganhol, Elizandra: 2 articles (10/2009 - 02/2009)
4.	Canedo, Andrés Delgado: 2 articles (10/2009 - 02/2009)
5.	Henriques, Amélia Teresinha: 2 articles (10/2009 - 02/2009)
6.	Klamt, Fabio: 2 articles (10/2009 - 02/2009)
7.	Lerner, Cléa: 2 articles (10/2009 - 02/2009)
8.	Moreira, José Cláudio Fonseca: 2 articles (10/2009 - 02/2009)
9.	Mothes, Beatriz: 2 articles (10/2009 - 02/2009)
10.	da Frota, Mario Luiz Conte: 2 articles (10/2009 - 02/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Familial Polythelia:

1.	tenaxIBA 09/03/2021 - "portroyalensis, Neopetrosia proxima, Xestospongia arenosa, Calyx podatypa, Shiphonodictyon xamaycaense, Acarnus innominatus, Iotrochota arenosa, Polymastia tenax, Svenzea cristinae, Svenzea flava, Svenzea tubulosa, Svenzea zeai, Timea stenosclera, Stellettinopsis megastylifera, Suberea flavolivescens. " 09/01/2008 - "Crude extracts from the sponges Myrmekioderma gyroderma, Myrmekioderma rea, Biemna cribaria, Cinachyrella kuekenthali, Iotrochota imminuta, Oceanapia peltata, Polymastia tenax, Desmapsamma anchorata, Spirastrella coccinea, Cribrochalina infundibulum and Oceanapia bartschi did not show any antimicrobial activity whatsoever." 08/01/2002 - "Novel cytotoxic oxygenated C29 sterols from the Colombian marine sponge Polymastia tenax." 08/01/2002 - "Three new sterols, 5alpha,6alpha-epoxy-24R-ethylcholest-8(14)-en-3beta,7alpha-diol (1), 5alpha,6alpha-epoxy-24R-ethylcholest-8-en-3beta,7alpha-diol (2), and 3beta-hydroxy-24R-ethylcholesta-5,8-dien-7-one (3), have been isolated from the marine sponge Polymastia tenax, collected in the Colombian Caribbean, and their structures established on the basis of extensive NMR and MS studies. "
2.	SterolsIBA 08/01/2002 - "Novel cytotoxic oxygenated C29 sterols from the Colombian marine sponge Polymastia tenax." 08/01/2002 - "Three new sterols, 5alpha,6alpha-epoxy-24R-ethylcholest-8(14)-en-3beta,7alpha-diol (1), 5alpha,6alpha-epoxy-24R-ethylcholest-8-en-3beta,7alpha-diol (2), and 3beta-hydroxy-24R-ethylcholesta-5,8-dien-7-one (3), have been isolated from the marine sponge Polymastia tenax, collected in the Colombian Caribbean, and their structures established on the basis of extensive NMR and MS studies. "
3.	5alpha,6alpha- epoxy- 24R- ethylcholest- 8- en- 3beta,7alpha- diolIBA 08/01/2002 - "Three new sterols, 5alpha,6alpha-epoxy-24R-ethylcholest-8(14)-en-3beta,7alpha-diol (1), 5alpha,6alpha-epoxy-24R-ethylcholest-8-en-3beta,7alpha-diol (2), and 3beta-hydroxy-24R-ethylcholesta-5,8-dien-7-one (3), have been isolated from the marine sponge Polymastia tenax, collected in the Colombian Caribbean, and their structures established on the basis of extensive NMR and MS studies. "
4.	3beta- hydroxy- 24R- ethylcholesta- 5,8- dien- 7- oneIBA 08/01/2002 - "Three new sterols, 5alpha,6alpha-epoxy-24R-ethylcholest-8(14)-en-3beta,7alpha-diol (1), 5alpha,6alpha-epoxy-24R-ethylcholest-8-en-3beta,7alpha-diol (2), and 3beta-hydroxy-24R-ethylcholesta-5,8-dien-7-one (3), have been isolated from the marine sponge Polymastia tenax, collected in the Colombian Caribbean, and their structures established on the basis of extensive NMR and MS studies. "
5.	5alpha,6alpha- epoxy- 24R- ethylcholest- 8(14)- en- 3beta,7alpha- diolIBA 08/01/2002 - "Three new sterols, 5alpha,6alpha-epoxy-24R-ethylcholest-8(14)-en-3beta,7alpha-diol (1), 5alpha,6alpha-epoxy-24R-ethylcholest-8-en-3beta,7alpha-diol (2), and 3beta-hydroxy-24R-ethylcholesta-5,8-dien-7-one (3), have been isolated from the marine sponge Polymastia tenax, collected in the Colombian Caribbean, and their structures established on the basis of extensive NMR and MS studies. "
6.	Gonadal Steroid Hormones (Sex Hormones)IBA 04/01/2017 - "Clinical manifestation of polymastia is due to sex hormones, especially during puberty, pregnancy and lactation. " 05/01/2007 - "Although polythelia is congenital in origin and is identifiable at childhood, polymastia may not be evident until the influence of sex hormones during puberty. " 01/01/2000 - "Ectopic breast tissue and polymastia may not appear until enhanced by sex hormones during puberty or early pregnancy. "
7.	16S Ribosomal RNAIBA 01/01/2013 - "Here, we investigated the sponge bacterial community and distribution patterns of microbes in three sympatric intertidal marine demosponges, Hymeniacidon perlevis, Ophlitaspongia papilla and Polymastia penicillus, from the Atlantic coast of Portugal using classical isolation techniques and 16S rRNA gene clone libraries. " 06/01/2011 - "Seventy-three bacterial isolates from the marine sponges Polymastia boletiformis, Axinella dissimilis and Haliclona simulans were identified as Pseudovibrio spp. using phylogenetic analysis of 16S rRNA gene sequences. " 08/01/2008 - "Denaturing gradient gel electrophoresis (DGGE)-based analyses of 16S rRNA, aprA, and amoA genes demonstrated that a phylogenetically diverse and complex microbial community was associated with the Caribbean deep-water sponge Polymastia cf. "
8.	Fatty Acids (Saturated Fatty Acids)IBA 09/01/2009 - "First total synthesis and antiprotozoal activity of (Z)-17-methyl-13-octadecenoic acid, a new marine fatty acid from the sponge Polymastia penicillus." 07/01/2009 - "The phospholipid fatty acid composition of the North-East Atlantic sponge Polymastia penicillus (South Brittany, France) was investigated. " 03/01/1985 - "The phospholipids of the sponge Polymastia gleneni contain saturated long chain (C22-30)-acetoxy fatty acids. "
9.	Complex MixturesIBA 02/01/2009 - "Here, we examined the anti-proliferative effects of crude extracts (aqueous and organic) of the Brazilian marine sponge Polymastia janeirensis in the U138MG human glioma cell line. " 09/01/2008 - "Crude extracts from the sponges Myrmekioderma gyroderma, Myrmekioderma rea, Biemna cribaria, Cinachyrella kuekenthali, Iotrochota imminuta, Oceanapia peltata, Polymastia tenax, Desmapsamma anchorata, Spirastrella coccinea, Cribrochalina infundibulum and Oceanapia bartschi did not show any antimicrobial activity whatsoever."
10.	Phospholipids (Phosphatides)FDA LinkGeneric 07/01/2009 - "The phospholipid fatty acid composition of the North-East Atlantic sponge Polymastia penicillus (South Brittany, France) was investigated. " 03/01/1985 - "The phospholipids of the sponge Polymastia gleneni contain saturated long chain (C22-30)-acetoxy fatty acids. "

Therapies and Procedures

1.	Operative Surgical Procedures 07/01/2007 - "In our 10-year experience, 208 patients were observed (138 polythelia and 70 polymastia) and 159 surgical procedures were performed, 97 for supernumerary nipple excision and 67 for accessory breast ablation. "
2.	Mastectomy (Mammectomy) 01/01/2017 - "Correction of Polymastia Vera Class I with Skin-sparing Mastectomy and Immediate Rib-sparing DIEP-Flap Reconstruction."
3.	Vulvectomy 12/01/2021 - "The patient underwent a left radical partial vulvectomy, with pathology revealing terminal duct lobular units consistent with polymastia. "