Halothane Hepatitis

01/01/1990 - "Based on a case report the necessity of including halothane hepatitis in differential diagnosis of postoperative jaundice is described. "
01/01/1990 - "[Halothane hepatitis in the differential diagnosis of postoperative jaundice]."
11/01/1990 - "These cases illustrate different clinical presentations of halothane hepatitis, such as delayed onset of jaundice or fever following halothane exposure. "
01/01/1990 - "Prevention of halothane hepatitis may be difficult, and the only clear way of reducing the incidence is to avoid re-exposure to halothane in those patients who have had a previous adverse reaction to the drug, demonstrated either by unexplained pyrexia or by jaundice. "
04/01/1978 - "A survey of postoperative jaundice throughout the United Kingdom allowed the detailed analysis of 76 patients with unexplained hepatitis following halothane anesthesia ("halothane hepatitis"). "

10/01/1986 - "Serum alanine aminotransferase should be investigated in all patients with postoperative pyrexia of unknown origin if mild forms of halothane hepatitis are to be discovered. "
11/01/1990 - "These cases illustrate different clinical presentations of halothane hepatitis, such as delayed onset of jaundice or fever following halothane exposure. "
01/01/1990 - "Prevention of halothane hepatitis may be difficult, and the only clear way of reducing the incidence is to avoid re-exposure to halothane in those patients who have had a previous adverse reaction to the drug, demonstrated either by unexplained pyrexia or by jaundice. "

03/01/2019 - "The HCFC-123-induced hepatitis showed similarities with halothane hepatitis, both of which may share pathophysiologic mechanisms. "
11/01/1985 - "We conclude that patients with a prior history of halothane hepatitis are at risk of inapparent circuit contamination-induced recurrent hepatitis. "
08/01/1977 - "The two case reports do not fit with typical isoniacid hepatitis or typical halothane hepatitis. "
05/01/1977 - "While specific immunologic technics are available to diagnose viral hepatitis, halothane hepatitis cannot presently be unequivocally diagnosed with available clinical, biochemical, immunologic, or pathologic technics. "
10/01/2004 - "In an area endemic of malaria, hepatitis and haemolysing conditions like sickle cell anaemia, the diagnosis of halothane hepatitis requires high index of suspicion. "

09/25/1985 - "Halothane hepatitis: toxicity or hypersensitivity?"
01/01/1976 - "[Relevance of clinical signs of hypersensitivity in cases of halothane hepatitis]."
01/01/1975 - "The hypothesis that "halothane hepatitis" is related to hypersensitivity to the agent is widely accepted. "
07/01/1970 - "[Halothane hepatitis and allergy]."
05/10/1969 - "Halothane: hepatitis or allergy?"

08/01/2000 - "On the seventh postoperative day the patient died and postmortem examination demonstrated centrilobular necrosis of the liver, with a histological pattern similar to changes associated with halothane hepatitis."
05/18/1996 - "Fulminant hepatic necrosis ("halothane hepatitis") is an unusual and often fatal complication of halothane anaesthesia. "
04/26/1986 - "The principal aetiologies were paracetamol-induced hepatic necrosis, viral hepatitis, halothane hepatitis and idiosyncratic drug reactions. "
04/01/1997 - "These protein neo-antigens stimulate an immune reaction that mediates severe hepatic necrosis ("halothane hepatitis"). "
07/01/2003 - "Cytochrome P4502E1(CYP2E1)-mediated oxidation of halothane to a reactive intermediate (trifluoroacyl chloride) that covalently binds to hepatic proteins forming trifluoroacetylated neoantigens is believed to be the initiating event in a complex immunologic cascade culminating in antibody formation and severe hepatic necrosis ('halothane hepatitis') in susceptible patients. "