Testicular Teratoma

A non-seminomatous germ cell tumor arising from the testis and characterized by the presence of various tissues which correspond to the different germinal layers (ENDODERM; MESODERM, and ECTODERM). Mature teratomas consist of adult tissues whereas immature teratomas consist of fetal tissues. The prognosis for pediatric patients is generally good, however, teratomas may metastasize in adolescent and adult patients. May be hereditary or caused by somatic mutations. OMIM: 273300

Also Known As:

Networked: 112 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Primitive Neuroectodermal Tumors (PNET)
2.	Osteosarcoma (Osteogenic Sarcoma)
3.	Adenocarcinoma
4.	Neoplasm Metastasis (Metastasis)
5.	Neoplasms (Cancer)

Experts

1.	Alkatan, Hind M: 1 article (03/2022)
2.	Almater, Abdullah I: 1 article (03/2022)
3.	Alromaih, Arwa Z: 1 article (03/2022)
4.	Fathaddin, Amany A: 1 article (03/2022)
5.	Chen, Haitao: 1 article (12/2021)
6.	Lei, Wei: 1 article (12/2021)
7.	Li, Gang: 1 article (12/2021)
8.	Li, Shuang: 1 article (12/2021)
9.	Liao, Man: 1 article (12/2021)
10.	Wang, Jun: 1 article (12/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Testicular Teratoma:

1.	Bleomycin (Blenoxane)FDA LinkGeneric 02/01/1982 - "Role of pulmonary function tests in the prevention of bleomycin pulmonary toxicity during chemotherapy for metastatic testicular teratoma." 01/01/1983 - "A 38-year-old patient is reported who received 615 mg bleomycin for therapy of a malignant testicular teratoma and in the following time developed numerous morphoea-like lesions, acrocyanosis, Raynaud's phenomenon, acrosclerosis, and cutaneous calcinosis. " 11/25/1975 - "A study, using the combination of Bleomycin and CCNU in 17 patients with metastatic testicular teratoma, is reported. " 10/01/1982 - "Adjuvant chemotherapy for testicular teratoma with Bleomycin and Vinblastine." 12/25/1981 - "Sequential chemotherapy with vinblastin and bleomycin, as well as adriamycin and cis-platin, was administered to 29 patients with disseminated malignant testicular teratoma. "
2.	Etoposide (VP 16)FDA LinkGeneric 06/01/2000 - "Effect of etoposide on experimental testicular teratoma in 129/SvJ mice." 04/15/1994 - "Mechanisms of resistance to VP-16 were monitored in a series of sublines of the human testicular teratoma cell line (SuSa) derived following exposure either to fractionated X-irradiation (DXR-10) or to VP-16 using pulsed 24-hr exposures (VP10) or continuous exposure conditions (VPC2, VPC3 and VPC4). " 04/15/1994 - "Multiple mechanisms of resistance in a series of human testicular teratoma cell lines selected for increasing resistance to etoposide." 06/01/2000 - "To study the effects of etoposide on experimental testicular teratoma in 129/SvJ mouse we analysed the tumour growth, differentiation, apoptosis and the localisation of mdr1 P-glycoprotein (mdr1-Pgp). " 03/02/1994 - "Three etoposide-selected resistant sublines of the SuSa testicular teratoma cell line expressing 9-, 21- and 33-fold levels of resistance, proved increasingly cross resistant to cisplatin with levels approximating to 3-, 4- and 6-fold in sublines VPC2, VPC3 and VPC4, respectively. "
3.	Hormones (Hormone)IBA 03/01/2016 - "We report an unusual case of early onset of puberty in obese boy with KS who presented with a unilateral non-hormone secreting testicular teratoma. " 09/15/1973 - " Prospective multicenter clinical trials should be done to evaluate the therapeutic value of hormones, alone or in combination with chemotherapy and irradiation in the management of malignant testicular teratoma."
4.	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 06/01/2000 - "To study the effects of etoposide on experimental testicular teratoma in 129/SvJ mouse we analysed the tumour growth, differentiation, apoptosis and the localisation of mdr1 P-glycoprotein (mdr1-Pgp). "
5.	Lomustine (CCNU)FDA Link 11/25/1975 - "A study, using the combination of Bleomycin and CCNU in 17 patients with metastatic testicular teratoma, is reported. "
6.	Cisplatin (Platino)FDA LinkGeneric 06/01/1994 - "Mechanisms of cisplatin resistance have been studied in two independently-selected sublines expressing clinically-relevant levels of resistance (3-fold) and established from a primary testicular teratoma obtained from previously untreated patients. " 07/01/1990 - "In vitro exposure of a human testicular teratoma continuous cell line to fractionated X-irradiation resulted in the expression of resistance to cisplatin. " 07/15/1978 - "[The effect of platinum diamminodichloride (cis-platinum) in the treatment of metastasized testicular teratoma]." 05/01/1991 - "From January 1978 to March 1989, 92 consecutive patients with metastatic testicular teratoma have been treated with cisplatin-based chemotherapy. " 01/01/1998 - "Frey's syndrome after cisplatin-based chemotherapy for testicular teratoma."
7.	Vinblastine (Vinblastine Sulfate)FDA Link 10/01/1982 - "Adjuvant chemotherapy for testicular teratoma with Bleomycin and Vinblastine." 06/01/1981 - "[Unusual course in 2 patients with testicular teratoma during vinblastine-cyclophosphamide chemotherapy]." 08/11/1979 - "Intensive chemotherapy with bleomycin and vinblastine was used as initial treatment in patients with advanced testicular teratoma and after relapse following lymph-node irradiation in patients with early-stage disease. " 06/01/1981 - "Because of our own experiences and because of the results in single agent chemotherapy this well tolerated vinblastine-cyclophosphamide combination is proposed as maintenance therapy for testicular teratoma. " 11/01/1982 - "Reduced platelet survival following chemotherapy with vinblastine, bleomycin and cis-platinum for testicular teratoma."
8.	DNA AdductsIBA 06/01/1994 - "Differential formation and enhanced removal of specific cisplatin-DNA adducts in two cisplatin-selected resistant human testicular teratoma sublines." 01/01/1994 - "Deficient repair of cisplatin-DNA adducts identified in human testicular teratoma cell lines established from tumours from untreated patients." 01/01/1994 - "We have now quantitated cisplatin cytotoxicity by clonogenic assay, and platinum (Pt)-DNA adduct formation and removal immunochemically in four other testicular teratoma continuous cell lines (GCT46, GCT27 clone 4, H32 and H12.1), all established from tissue from non-drug-treated patients. "
9.	Tumor Biomarkers (Tumor Markers)IBA 01/01/1995 - "Prognostic significance of early serum tumor marker half-life in metastatic testicular teratoma." 10/01/2020 - "We propose that all stage II NSGCT patients with pure testicular teratoma, normal serum tumor markers, and with RP cystic metastases on imaging can safely be treated with primary RPLND. "
10.	SeleniumIBA 01/01/2020 - "Activation of Signal Pathways of Apoptosis under Conditions of Prolonged ER-Stress Caused by Exposure of Mouse Testicular Teratoma Cells to Selenium-Containing Compounds." 05/01/1988 - "Haematocrit and glutathione peroxidase activity in blood, as well as selenium levels in blood, erythrocytes and plasma, were determined in 15 patients during four courses of cisplatin combination treatment for testicular teratoma. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 03/01/1991 - "Case 2. A 30-year-old patient with testicular teratoma, stage IIIA, on the right side gained complete remission after a CDDP containing chemotherapy. " 07/01/2017 - "We report a case of metastatic CTT in a patient with primary testicular teratoma without prior chemotherapy. " 01/01/1995 - "A 27 years old man was treated after surgery and classic chemotherapy for a right testicular teratoma (stage IV). " 03/01/1994 - "Locally recurrent testicular teratoma successfully treated without chemotherapy." 09/01/1991 - "Twenty patients with metastatic testicular teratoma underwent surgery for residual disease after chemotherapy. "
2.	Orchiectomy (Orchidectomy) 03/22/2014 - "Inguinal radical orchiectomy is the traditional gold standard treatment for benign testicular teratoma in children. " 11/01/2015 - "Later on, the patient underwent bilateral radical orchiectomy, with pathology reporting a synchronous bilateral testicular teratoma. " 10/01/2006 - "We describe the application of this technique in the case of a patient who had previously undergone right radical orchidectomy for testicular teratoma, to discover the source of persistently raised tumour markers following the operation. " 07/01/1988 - "Seminal analysis was performed within 2 months of orchiectomy on 97 patients with clinical Stage I malignant testicular teratoma managed by surveillance following orchiectomy. " 05/01/1988 - "A case of metastatic testicular teratoma is reported where histological evidence of metastatic disease was obtained 12 years after orchidectomy. "
3.	Combination Drug Therapy (Combination Chemotherapy) 11/01/1991 - "We describe a patient with widely metastatic testicular teratoma who responded to intensive combination chemotherapy but developed a lung abscess in a necrotic tumour cavity, leading to death before surgical resection of residual lesions could take place. " 07/01/1986 - "A man aged 33 with poorly controlled hypertension who had been treated with radiotherapy and combination chemotherapy for testicular teratoma 8 years earlier was found on arteriography to have 75% stenosis of the left renal artery and occlusion of the right renal artery. " 01/01/2018 - "Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male." 01/01/1991 - "Combination chemotherapy with bleomycin, etoposide and cisplatin (BEP) for metastatic testicular teratoma: long-term follow-up." 01/01/1989 - "The pharmacokinetics of carboplatin and etoposide were studied in four testicular teratoma patients receiving four courses each of combination chemotherapy consisting of etoposide (120 mg/m2 daily x 3); bleomycin (30 mg weekly) and carboplatin. "
4.	Nursing Care 02/05/1981 - "Nursing care study: testicular teratoma."
5.	Lymph Node Excision (Lymph Node Dissection) 07/01/2021 - "Retroperitoneal Lymph Node Dissection Versus Surveillance for Adult Early Stage Pure Testicular Teratoma: A Nationwide Analysis." 12/01/2003 - "Clinical outcome after retroperitoneal lymphadenectomy of patients with pure testicular teratoma." 10/01/1999 - "A 7-year audit in a single centre of the results of the modified template retroperitoneal lymph node dissection for testicular teratoma." 12/01/1985 - "The accuracy of CT scanning prior to para-aortic lymphadenectomy was assessed in 108 patients with metastatic testicular teratoma. " 07/01/2021 - "Following radical orchiectomy, surveillance and primary retroperitoneal lymph node dissection (RPLND) are acceptable options for the management of early stage pure testicular teratoma in adult patients; however, there is no uniform consensus. "