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EVP 4593

an NF-kappaB pathway inhibitor; structure in first source

Also Known As:

EVP-4593; EVP4593; N(4)-(2-(4-phenoxyphenyl)ethyl)-4,6-quinazolinediamine; QNZ quinazolinediamine

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Phenyl Ethers: 8
        EVP 4593: 3
- Ethers: 242
  - Phenyl Ethers: 8
    - EVP 4593: 3
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - EVP 4593: 3

Experts

1.	Bi, Qi: 1 article (01/2021)
2.	He, Yan: 1 article (01/2021)
3.	Jie-Feng,: 1 article (01/2021)
4.	Meng, Jian-Jun: 1 article (01/2021)
5.	Tu, Rong-Hui: 1 article (01/2021)
6.	Wang, Dong-Xiao: 1 article (01/2021)
7.	Wen, Hong: 1 article (01/2021)
8.	Zhong, Guo-Qiang: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2022 - "We compared the specificity and mode of action of CI inhibitors metformin, BAY 87-2243 and EVP 4593 using cancer cell models devoid of CI. "
2.	Ischemia 01/01/2021 - "Rats in the sham group underwent thoracotomy, passing the ligature through the heart but without tying it (150 min), and the other seven groups were subjected to 30 min of anterior descending coronary artery occlusion followed by 2 h of reperfusion and the following treatments: I/R (30 min of ischemia and followed by 2 h of reperfusion); ischemic postconditioning (IPostC, 30 s of ischemia altered with 30 s of reperfusion, repeated for three cycles, and followed by reperfusion for 2 h); MP (0.3 mg/kg morphine administration 10 min before reperfusion); MP combined with the HSP90 inhibitor geldanamycin (GA, 1 mg/kg); MP combined with the Akt inhibitor GSK-690693 (GSK, 20 mg/kg); and MP combined with the C5a inhibitor PMX205 (PMX, 1 mg/kg/day, administration via drinking water for 28 days) and MP combined with the NF-κB inhibitor EVP4593 (QNZ, 1 mg/kg). "
3.	Huntington Disease (Huntington's Disease) 12/11/2022 - "We summarized the accumulated data about EVP4593 and focused on its activities in different models of Huntington's disease (HD), including patient-specific iPSCs-based neurons. " 12/11/2022 - "The Mystery of EVP4593: Perspectives of the Quinazoline-Derived Compound in the Treatment of Huntington's Disease and Other Human Pathologies."

Related Drugs and Biologics

1.	Drinking Water
2.	Quinazolines
3.	Morphine (MS Contin)
4.	Metformin (Glucophage)
5.	hydrocinnamate- cyclo(ornithyl- prolyl- cyclohexylalanyl- tryptophyl- arginyl)
6.	salicylhydroxamic acid (SHAM)
7.	geldanamycin
8.	1- cyclopropyl- 4- (4- ((5- methyl- 3- (3- (4- (trifluoromethoxy)phenyl)- 1,2,4- oxadiazol- 5- yl)- 1H- pyrazol- 1- yl)methyl)pyridin- 2- yl)piperazine

Related Therapies and Procedures

1.	Ischemic Postconditioning
2.	Thoracotomy
3.	Ligation