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ISC-4 compound

structure in first source

Also Known As:

phenylbutyl isoselenocyanate

Networked: 4 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organoselenium Compounds: 63
  - ISC-4 compound: 4

Experts

1.	Sharma, Arun K: 4 articles (01/2018 - 07/2011)
2.	Amin, Shantu: 3 articles (01/2013 - 07/2011)
3.	Irby, Rosalyn B: 2 articles (01/2013 - 07/2011)
4.	Amin, Shantu G: 1 article (01/2018)
5.	Jiang, Cheng: 1 article (01/2018)
6.	Karelia, Deepkamal: 1 article (01/2018)
7.	Lu, Junxuan: 1 article (01/2018)
8.	Pramanik, Kartick: 1 article (01/2018)
9.	Wu, Wei: 1 article (01/2018)
10.	Allen, Joshua E: 1 article (01/2013)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 01/01/2013 - "Phenylbutyl isoselenocyanate (ISC-4) is an Akt inhibitor with demonstrated preclinical efficacy against melanoma and colon cancer. " 01/01/2018 - "Previous studies have established the in vivo bioavailability and efficacious dosages of phenylbutyl isoselenocyanate (ISC-4), a selenium-substituted isothiocyanate, against mouse xenograft models of human melanoma and colorectal cancer. "
2.	Colonic Neoplasms (Colon Cancer) 01/01/2013 - "Phenylbutyl isoselenocyanate (ISC-4) is an Akt inhibitor with demonstrated preclinical efficacy against melanoma and colon cancer. "
3.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2018 - "Previous studies have established the in vivo bioavailability and efficacious dosages of phenylbutyl isoselenocyanate (ISC-4), a selenium-substituted isothiocyanate, against mouse xenograft models of human melanoma and colorectal cancer. "
4.	Neoplasms (Cancer) 07/01/2011 - "In this study we investigated (i) the effects of the Akt inhibitor, phenylbutyl isoselenocyanate (ISC-4), on tumor growth in nude mice and (ii) bystander effect of Par-4-overexpressing cells on wild-type tumor growth. "
5.	Lung Neoplasms (Lung Cancer) 11/01/2011 - "Through extensive structure-activity relationship studies, we recently identified a novel agent phenylbutyl isoselenocyanate (ISC-4), designed on the basis of naturally occurring isothiocyanates well known for their lung cancer prevention properties, as a potential chemopreventive agent. "

Related Drugs and Biologics

1.	Isothiocyanates
2.	Selenium
3.	isothiocyanic acid
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	Androgen Receptors (Androgen Receptor)