Atu027

10/26/2020 - "This trial was designed to assess the safety, pharmacokinetics and efficacy of Atu027 in combination with gemcitabine in advanced pancreatic carcinoma (APC). "
12/01/2008 - "We show the efficacy of Atu027 in orthotopic mouse models for prostate and pancreatic cancers with significant inhibition of tumor growth and lymph node metastasis formation. "

12/20/2014 - "First-in-human phase I study of the liposomal RNA interference therapeutic Atu027 in patients with advanced solid tumors."
12/20/2014 - "Atu027 was safe in patients with advanced solid tumors, with 41% of patients having stable disease for at least 8 weeks. "
12/20/2014 - "Atu027 has previously been shown to inhibit local tumor invasion as well as lymph node and pulmonary metastasis in mouse cancer models. "
12/20/2014 - "This first-in-human study aimed to assess the safety, tolerability, and pharmacokinetics of Atu027 while evaluating therapeutic effects on both primary tumors and metastatic lesions. "
12/20/2014 - "Thirty-four patients with advanced solid tumors received 10 escalating doses of Atu027 without premedication, as one single followed by eight intravenous infusions twice per week during a 28-day cycle. "

11/15/2010 - "Atu027, a novel RNA interference therapeutic, has been shown to inhibit lymph node metastasis in orthotopic prostate cancer mouse models. "
12/01/2008 - "We show the efficacy of Atu027 in orthotopic mouse models for prostate and pancreatic cancers with significant inhibition of tumor growth and lymph node metastasis formation. "

11/15/2010 - "The aim of this study is to elucidate the pharmacologic activity of Atu027 in inhibiting hematogenous metastasis to the target organ lung in four different preclinical mouse models. "
11/15/2010 - "Atu027 prevents pulmonary metastasis in experimental and spontaneous mouse metastasis models."
11/15/2010 - "Intravenous administration of Atu027 prevents pulmonary metastasis. "
12/20/2014 - "Atu027 has previously been shown to inhibit local tumor invasion as well as lymph node and pulmonary metastasis in mouse cancer models. "
11/15/2010 - "Atu027 can be considered as a potent drug for preventing lung metastasis formation, which might be suitable for preventing hematogenous metastasis in addition to standard cancer therapy."

11/15/2010 - "Atu027 compared with vehicle or control small interfering RNA lipoplexes was tested in two experimental lung metastasis models (Lewis lung carcinoma, B16V) and spontaneous metastasis mouse models (MDA-MB-435, MDA-MB-231, mammary fat pad). "