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flubrobenguane

structure in first source

Also Known As:

LMI-1195; LMI1195; N-(3-bromo-4-(3-(18F)fluoro-propoxy)benzyl)guanidine; flurobenguan

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Fluorobenzenes: 14
        flubrobenguane: 5
  - Halogenated Hydrocarbons: 42
    - Fluorinated Hydrocarbons: 4
      - Fluorobenzenes: 14
        flubrobenguane: 5
- Amidines: 14
  - Guanidines: 29
    - flubrobenguane: 5

Experts

1.	Orlandi, Cesare: 3 articles (01/2021 - 12/2019)
2.	Robinson, Simon: 3 articles (01/2021 - 12/2019)
3.	Beanlands, Rob S B: 2 articles (01/2020 - 12/2019)
4.	Garrard, Linda: 2 articles (01/2020 - 12/2019)
5.	Hadizad, Tayebeh: 2 articles (01/2020 - 12/2019)
6.	Mielniczuk, Lisa M: 2 articles (01/2020 - 12/2019)
7.	Walter, Olga: 2 articles (01/2020 - 12/2019)
8.	Zelt, Jason G E: 2 articles (01/2020 - 12/2019)
9.	deKemp, Robert A: 2 articles (01/2020 - 12/2019)
10.	Eiber, Matthias: 1 article (01/2021)

Related Diseases

1.	Cardiomyopathies (Cardiomyopathy) 01/01/2020 - "Correction to: PET imaging of sympathetic innervation with [18F]Flubrobenguane vs [11C]mHED in a patient with ischemic cardiomyopathy." 12/01/2019 - "PET imaging of sympathetic innervation with [18F]Flurobenguan vs [11C]mHED in a patient with ischemic cardiomyopathy."
2.	Pheochromocytoma 11/01/2022 - "Numerous radiotracers for assessment of adrenal incidentalomas ([ 18 F]FDG; [ 123 I]IMTO/IMAZA), ACC ([ 123 I]IMTO/IMAZA; [ 18 F]FDG; [ 68 Ga]PentixaFor), pheochromocytomas and paragangliomas ([ 123 I]mIBG; [ 18 F]flubrobenguane; [ 18 F]AF78; [ 68 Ga]DOTATOC/-TATE), or primary aldosteronism ([ 11 C]MTO, [ 68 Ga]PentixaFor) are currently available and have been extensively investigated in recent years. "
3.	Paraganglioma (Paragangliomas) 11/01/2022 - "Numerous radiotracers for assessment of adrenal incidentalomas ([ 18 F]FDG; [ 123 I]IMTO/IMAZA), ACC ([ 123 I]IMTO/IMAZA; [ 18 F]FDG; [ 68 Ga]PentixaFor), pheochromocytomas and paragangliomas ([ 123 I]mIBG; [ 18 F]flubrobenguane; [ 18 F]AF78; [ 68 Ga]DOTATOC/-TATE), or primary aldosteronism ([ 11 C]MTO, [ 68 Ga]PentixaFor) are currently available and have been extensively investigated in recent years. "
4.	Neuroblastoma 07/01/2011 - "Similarly, LMI1195 uptake kinetics examined in a human neuroblastoma cell line had Km and Vmax values of 1.44 ± 0.76 μmol/L and 6.05 ± 3.09 pmol/million cells per minute, comparable to NE (2.01 ± 0.85 μmol/L and 6.23 ± 1.52 pmol/million cells per minute). "
5.	Neoplasms (Cancer) 01/01/2021 - "Results:18F-flubrobenguane showed a reproducible, stable biodistribution, with the highest SUVmax and SUVmean being in the thyroid gland (30.3 ± 2.2 and 22.5 ± 1.6, respectively), pancreas (12.2 ± 0.8 and 9.5 ± 0.7, respectively), and tumor lesions (16.8 ± 1.7 and 10.1 ± 1.1, respectively) and the lowest SUVmax and SUVmean being in muscle (1.1 ± 0.06 and 0.7 ± 0.04, respectively) and the lung (2.5 ± 0.17 and 1.85 ± 0.13, respectively). "

Related Drugs and Biologics

1.	3-Iodobenzylguanidine (Iobenguane)
2.	Edotreotide (SMT 487)
3.	68Ga-pentixafor