HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

3- fluoro- N- (2- (1- piperidinyl)ethyl)- 5- (trifluoromethyl)benzamide

inhibits conformational change of group I influenza viruses at low pH; structure in first source

Also Known As:

CL-385319

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Liu, Shuwen: 3 articles (12/2017 - 06/2011)
2.	Yang, Jie: 3 articles (12/2017 - 06/2011)
3.	Li, Runming: 2 articles (11/2012 - 06/2011)
4.	Zhu, Zhibo: 2 articles (11/2012 - 06/2011)
5.	Chen, Lizhu: 1 article (12/2017)
6.	Ding, Yi: 1 article (12/2017)
7.	Wu, Wenjiao: 1 article (12/2017)
8.	Yang, Zifeng: 1 article (12/2017)
9.	Chen, Zhipeng: 1 article (11/2012)
10.	Xiao, Gaokeng: 1 article (11/2012)

Related Diseases

1.	Infections 06/25/2011 - "Here we show that CL-385319 is effective in inhibiting infection of highly pathogenic H5N1 influenza A virus in Madin-Darby Canine Kidney (MDCK) cells with an IC50 of 27.03±2.54 μM. " 06/25/2011 - "These findings suggest that CL-385319 can serve as a lead for development of novel virus entry inhibitors for preventing and treating H5N1 influenza A virus infection." 06/25/2011 - "CL-385319, an N-substituted piperidine, is effective in inhibiting infection of H1-, H2-, and to a lesser extent, H3-typed influenza A viruses by interfering with the fusogenic function of the viral hemagglutinin. " 11/01/2012 - "We reported previously that a small molecule named CL-385319 could inhibit H5N1 influenza virus infection by targeting hemagglutinin, the envelope protein mediating virus entry. "
2.	Virus Diseases (Viral Diseases) 06/25/2011 - "CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry."
3.	Human Influenza (Influenza) 12/01/2017 - "Here, lethal dose of mouse-adapted H1N1 strain PR8A/PR/8/34 was inoculated C57BL/6 mice to detect the anti-influenza activity of andrographolide, the active component of traditional Chinese medicinal herb Andrographis paniculata, with or without influenza virus entry inhibitor CL-385319. "
4.	Influenza in Birds (Avian Flu) 06/25/2011 - "CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry."

Related Drugs and Biologics

1.	Viral Hemagglutinins
2.	piperidine
3.	Proteins (Proteins, Gene)
4.	Hemagglutinins (Hemagglutinin)
5.	andrographolide