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5- (3',5'- dichlorobiphenyl- 4- yl)- 2,3- dihydroxy- 4- (2- methoxyacetamido)pentanoic acid

inhibits Cdc24; structure in first source

Also Known As:

CC 0651; CC-0651; CC0651

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - 5-(3',5'-dichlorobiphenyl-4-yl)-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid: 2
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        5-(3',5'-dichlorobiphenyl-4-yl)-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid: 2

Experts

1.	Chen, Lei: 1 article (01/2020)
2.	Deng, Lu: 1 article (01/2020)
3.	Meng, Tong: 1 article (01/2020)
4.	Wang, Ping: 1 article (01/2020)
5.	Wei, Wenyi: 1 article (01/2020)
6.	Al-Hakim, Abdallah: 1 article (06/2011)
7.	Ceccarelli, Derek F: 1 article (06/2011)
8.	Chou, Yang-Chieh: 1 article (06/2011)
9.	Cox, Sarah: 1 article (06/2011)
10.	Dhe-Paganon, Sirano: 1 article (06/2011)

Related Diseases

1.

Neoplasms (Cancer)

06/24/2011 - "CC0651 analogs inhibited proliferation of human cancer cell lines and caused accumulation of the SCF(Skp2) substrate p27(Kip1). "
01/01/2020 - "In addition, MLN7243 and MLN4924 (targeting the E1 enzyme), Leucettamol A and CC0651 (targeting the E2 enzyme), nutlin and MI-219 (targeting the E3 enzyme), and compounds G5 and F6 (targeting DUB activity) have also shown potential in preclinical cancer treatment. "

Related Drugs and Biologics

1.	S-Phase Kinase-Associated Proteins (Skp1 Protein)
2.	Enzymes
3.	MI-219
4.	leucettamol A
5.	pevonedistat
6.	TAK-243