HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

3- (3- chlorophenoxymethyl)- 1- (tetrahydropyran- 4- yl)- 1H- pyrazolo(3,4- d)pyrimidin- 4- ylamine

inhibits casein kinase 1 epsilon; structure in first source

Also Known As:

PF 4800567; PF-4800567; PF4800567

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - 3-(3-chlorophenoxymethyl)-1-(tetrahydropyran-4-yl)-1H-pyrazolo(3,4-d)pyrimidin-4-ylamine: 4
  - Pyrimidines: 510
    - 3-(3-chlorophenoxymethyl)-1-(tetrahydropyran-4-yl)-1H-pyrazolo(3,4-d)pyrimidin-4-ylamine: 4

Experts

1.	Guo, Sujuan: 1 article (11/2018)
2.	Kelly, Deborah F: 1 article (11/2018)
3.	Liang, Yanping: 1 article (11/2018)
4.	Murphy, Susan: 1 article (11/2018)
5.	Pham, Lily: 1 article (11/2018)
6.	Pridham, Kevin J: 1 article (11/2018)
7.	Sheng, Zhi: 1 article (11/2018)
8.	Varghese, Robin T: 1 article (11/2018)
9.	Young, Sarah: 1 article (11/2018)
10.	Agarwal, Apeksha: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 06/02/2011 - "The recent development of the nanomolar CK1δ/ɛ-selective inhibitor, PF670462 (PF670) and the CK1ɛ-selective inhibitor PF4800567 (PF480) offers an opportunity to further test the role of CK1δ/ɛ in cancer. " 02/19/2016 - "The invasion capability in colon cancer cells and xenograft lung tumor nodules induced by a DDX3-overexpressing T84 stable clone in tail-vein injection model were nearly suppressed by inhibitors of CK1ε (PF4800567) and β-catenin/TCF signaling (XAV939). "
2.	Wounds and Injuries (Trauma) 01/01/2017 - "The addition of recombinant TSP-1, conditioned media from cultured astrocytes at early stages of trauma, or the CK1ε inhibitor PF4800567 hydrochloride to traumatized cultured neurons reduced levels of p-TDP-43, and reversed the trauma-induced decline in NR1 subunit of the NMDA receptor and PSD95 levels. "
3.	Glioblastoma (Glioblastoma Multiforme) 11/01/2018 - "The CK1ε inhibitor IC261, but not PF-4800567, activated β-catenin and blocked the growth of glioblastoma cells and glioblastoma stem cells. "
4.	Colonic Neoplasms (Colon Cancer) 02/19/2016 - "The invasion capability in colon cancer cells and xenograft lung tumor nodules induced by a DDX3-overexpressing T84 stable clone in tail-vein injection model were nearly suppressed by inhibitors of CK1ε (PF4800567) and β-catenin/TCF signaling (XAV939). "

Related Drugs and Biologics

1.	Catenins
2.	Thrombospondin 1
3.	Conditioned Culture Media
4.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
5.	XAV939
6.	PF-670462
7.	IC 261