vernolide-A

01/01/2012 - "These results indicate that vernolide-A could inhibit the metastatic progression of B16F-10 melanoma cells in mice."
01/01/2012 - "(3)H-thymidine proliferation assay showed that vernolide-A could inhibit the proliferation of B16F-10 melanoma cells in vitro. "
09/01/2011 - "All these results demonstrate that vernolide-A could enhance the immune response against metastatic progression of B16F-10 melanoma cells in mice."
01/01/2012 - "The inhibitory effect of vernolide-A (C(21)H(28)O(7)) on lung metastasis induced by B16F-10 melanoma cells was studied using C57BL/6 mice. "
07/01/2011 - "In this study, we investigated the effect of vernolide-A on the induction of apoptosis as well as its regulatory effect on the activation of transcription factors in B16F-10 melanoma cells. "

02/01/2012 - "Administration of V. cinerea and vernolide-A significantly enhanced natural killer (NK) cell activity in both normal as well as tumor-bearing animals, and the activity was observed earlier than in tumor-bearing control animals. "
02/01/2012 - "and vernolide-A on cell-mediated immune (CMI) response was studied in normal as well as tumor-bearing BALB/c mice. "
01/01/2012 - "Vernolide-A was administered in three different modalities such as simultaneously with tumor, prophylactic to tumor and after tumor development. "
01/01/2011 - "Vernolide-A administration significantly reduced the tumor volume of radiation-exposed mice. "
01/01/2011 - "We investigated the effect of vernolide-A on the inhibition of radiation-induced tumor angiogenesis in C57BL/6 mice. "

01/01/2012 - "Maximum inhibition in the metastasis was observed when vernolide-A was administered simultaneously with tumor. "
01/01/2012 - "The inhibitory effect of vernolide-A (C(21)H(28)O(7)) on lung metastasis induced by B16F-10 melanoma cells was studied using C57BL/6 mice. "
09/01/2011 - "In addition, vernolide-A significantly down-regulated the serum levels of proinflammatory cytokines such as IL-1β, IL-6, tumor necrosis factor-alpha (TNF-α), and granulocyte-macrophage colony-stimulating factor (GM-CSF) during metastasis. "

01/01/2011 - "Vernolide-A inhibits radiation-induced hypoxia-mediated tumor angiogenesis by regulating HIF-1α, MMP-2, MMP-9, and VEGF."
01/01/2011 - "Vernolide-A also caused a significant inhibition in the invasion of irradiated B16F-10 melanoma cells across the collagen matrix, and inhibited the radiation-induced gene expression of hypoxia-inducible transcription factor-1α (HIF-1α) and VEGF in B16F-10 cells and VEGF receptor (Flk-1) expression in human umbilical vein endothelial cells. "