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N- (2- (3,4- dimethoxyphenyl)- 2- oxoethyl)- N- methyl- 3- (3- pyridyl)- 2- propenamide

a PDE IV inhibitor; structure in first source

Also Known As:

TJN 598; TJN-598; TJN598

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Acrylamides: 12
    - N-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)-N-methyl-3-(3-pyridyl)-2-propenamide: 1
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acrylates: 212
      - Acrylamides: 12
        N-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)-N-methyl-3-(3-pyridyl)-2-propenamide: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - N-(2-(3,4-dimethoxyphenyl)-2-oxoethyl)-N-methyl-3-(3-pyridyl)-2-propenamide: 1

Experts

1.	Hasegawa, Yoshihiro: 1 article (02/2011)
2.	Hattori, Tomohisa: 1 article (02/2011)
3.	Kase, Yoshio: 1 article (02/2011)
4.	Koseki, Junichi: 1 article (02/2011)
5.	Maruyama, Hirobumi: 1 article (02/2011)
6.	Sadakane, Chiharu: 1 article (02/2011)
7.	Shindo, Shoichiro: 1 article (02/2011)
8.	Takeda, Hiroshi: 1 article (02/2011)
9.	Takeda, Shuichi: 1 article (02/2011)

Related Diseases

1.	Glomerulonephritis 02/01/2011 - "This study was performed to elucidate the anti-nephritic effects of TJN-598, a new chemical compound derived from herbal components, on experimental mesangial proliferative glomerulonephritis. "
2.	Nephritis 02/01/2011 - "The addition of both TJN-598 and rolipram to the culture supernatant inhibited both increased expression of TGF-β1 and increases in levels of TNF-α in glomeruli isolated from rats with anti-Thy1 nephritis in a dose-dependent manner. " 02/01/2011 - "Effects of TJN-598, a new selective phosphodiesterase type IV inhibitor on anti-Thy1 nephritis in rats." 02/01/2011 - "Furthermore, administration of TJN-598 inhibited increases in the levels of TGF-β1 protein derived from glomeruli with anti-Thy-1 nephritis. " 02/01/2011 - "Second, to investigate the effects of TJN-598 and rolipram, which are typical PDEIV inhibitors, on the production of tumor necrosis factor (TNF)-α and transforming growth factor (TGF)-β1, glomeruli were isolated from rats with anti-Thy1 nephritis and incubated with the test drugs in vitro for 48 h. "

Related Drugs and Biologics

1.	Rolipram
2.	Transforming Growth Factors (Transforming Growth Factor)
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Proteins (Proteins, Gene)
5.	Phosphoric Diester Hydrolases (Phosphodiesterases)
6.	anti-Thy antibody