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4-methyl-3-nitrobenzoic acid

a migration inhibitor, prevents breast cancer metastasis in SCID mice

Also Known As:

4-methyl-3-nitro-benzoic acid

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        Nitrobenzoates: 3
        4-methyl-3-nitrobenzoic acid: 2
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - Nitrobenzoates: 3
        4-methyl-3-nitrobenzoic acid: 2

Experts

1.	Chen, Peng: 2 articles (09/2011 - 06/2011)
2.	Guo, Hua: 2 articles (09/2011 - 06/2011)
3.	Hao, Xishan: 2 articles (09/2011 - 06/2011)
4.	Li, Menghui: 2 articles (09/2011 - 06/2011)
5.	Zhang, Ning: 2 articles (09/2011 - 06/2011)
6.	Liu, Zhe: 1 article (09/2011)
7.	Ma, Ning: 1 article (09/2011)
8.	Zhang, Xiaofang: 1 article (09/2011)
9.	Blake, David J: 1 article (06/2011)
10.	Kong, Xiaoni: 1 article (06/2011)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2011 - "Taken together, these results suggest that 4-methyl-3-nitrobenzoic acid is a potent inhibitor of cancer cell chemotaxis and may be developed into a novel antimetastasis drug." 09/01/2011 - "In a previous high-throughput screening of 20,000 compounds to identify inhibitors of cancer cell migration, 4-methyl-3-nitrobenzoic acid was found to inhibit the migration of nine tumor cell lines. " 09/01/2011 - "The present study used the human non-small cell lung cancer cell (NSCLC) treatment with 4-methyl-3-nitrobenzoic acid significantly inhibited epithelial growth factor (EGF)-induced chemotaxis and chemokinesis of cancer cells in NSCLC cells. "
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/01/2011 - "The present study used the human non-small cell lung cancer cell (NSCLC) treatment with 4-methyl-3-nitrobenzoic acid significantly inhibited epithelial growth factor (EGF)-induced chemotaxis and chemokinesis of cancer cells in NSCLC cells. "
3.	Breast Neoplasms (Breast Cancer) 06/01/2011 - "In this study, MTT assay revealed that 4-methyl-3-nitro-benzoic acid (MNBA) had no effect on cell viability and did not interfere with cell cycle in any breast cancer cell lines tested. " 06/01/2011 - "4-Methyl-3-nitro-benzoic acid, a migration inhibitor, prevents breast cancer metastasis in SCID mice."
4.	Neoplasm Metastasis (Metastasis) 06/01/2011 - "4-Methyl-3-nitro-benzoic acid, a migration inhibitor, prevents breast cancer metastasis in SCID mice."
5.	Lung Neoplasms (Lung Cancer) 09/01/2011 - "Effect of 4-methyl-3-nitrobenzoic acid on non‑small cell lung cancer cell migration."

Related Drugs and Biologics

1.	Intercellular Signaling Peptides and Proteins (Growth Factors)
2.	Epidermal Growth Factor (EGF)