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1'- benzyl- 3- (2- fluoroethyl)- 3H- spiro((2)benzofuran- 1,4'- piperidine)

a sigma1 receptor ligand; structure in first source

Also Known As:

(18F)fluspidine; 1'-benzyl-3-(2-(18F)fluoroethyl)-3H-spiro((2)benzofuran-1,4'-piperidine); fluspidine

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - 1'-benzyl-3-(2-fluoroethyl)-3H-spiro((2)benzofuran-1,4'-piperidine): 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - 1'-benzyl-3-(2-fluoroethyl)-3H-spiro((2)benzofuran-1,4'-piperidine): 3

Experts

1.	Brust, Peter: 3 articles (01/2021 - 03/2018)
2.	Patt, Marianne: 2 articles (01/2021 - 05/2020)
3.	Sabri, Osama: 2 articles (01/2021 - 05/2020)
4.	Deuther-Conrad, Winnie: 2 articles (05/2020 - 03/2018)
5.	Fischer, Steffen: 2 articles (05/2020 - 03/2018)
6.	Kranz, Mathias: 2 articles (05/2020 - 03/2018)
7.	Barthel, Henryk: 1 article (01/2021)
8.	Becker, Georg A: 1 article (01/2021)
9.	Bronzel, Marcus: 1 article (01/2021)
10.	Gerhards, Thilo: 1 article (01/2021)

Related Diseases

1.	Huntington Disease (Huntington's Disease) 01/01/2021 - "Sigma-1 and dopamine D2/D3 receptor occupancy of pridopidine in healthy volunteers and patients with Huntington disease: a [18F] fluspidine and [18F] fallypride PET study."
2.	Glioblastoma (Glioblastoma Multiforme) 05/06/2020 - "Sigma-1 Receptor Positron Emission Tomography: A New Molecular Imaging Approach Using (S)-(-)-[18F]Fluspidine in Glioblastoma." 03/20/2018 - "Two Sig1R-specific radiolabeled enantiomers (S)-(-)- and (R)-(+)-[18F]fluspidine were investigated in several tumor cell lines including melanoma, squamous cell/epidermoid carcinoma, prostate carcinoma, and glioblastoma. "
3.	Neoplasms (Cancer) 03/20/2018 - "Bridging from Brain to Tumor Imaging: (S)-(-)- and (R)-(+)-[18F]Fluspidine for Investigation of Sigma-1 Receptors in Tumor-Bearing Mice."
4.	Melanoma (Melanoma, Malignant) 03/20/2018 - "Two Sig1R-specific radiolabeled enantiomers (S)-(-)- and (R)-(+)-[18F]fluspidine were investigated in several tumor cell lines including melanoma, squamous cell/epidermoid carcinoma, prostate carcinoma, and glioblastoma. "
5.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 03/20/2018 - "Two Sig1R-specific radiolabeled enantiomers (S)-(-)- and (R)-(+)-[18F]fluspidine were investigated in several tumor cell lines including melanoma, squamous cell/epidermoid carcinoma, prostate carcinoma, and glioblastoma. "

Related Drugs and Biologics

1.	Dopamine (Intropin)
2.	fallypride
3.	pridopidine
4.	Sigma-1 Receptor