1-(propoxymethyl)maleimide

04/10/2015 - "Second, MIRA-1 acute toxicity was independent of p53, since it occurred in human normal cells with increased or silenced p53 expression level, in cancer cells derived from solid or liquid tumors, with either mutated or wt TP53, and in cancer cells devoid of p53. "
04/10/2015 - "Here, we devised a strategy to examine the effects of MIRA-1 on a variety of human normal cells and cancer cell lines. "
04/29/2014 - "However, anti-tumour activity of MIRA-1 in haematological malignancies including multiple myeloma (MM) is unknown. "
08/26/2005 - "MIRA-1 induced mutant p53-dependent cell death in different human tumor cells carrying tetracycline-regulated mutant p53. "
01/25/2011 - "Exposure to NSC 19630 sensitized cancer cells to the G-quadruplex-binding compound telomestatin or a poly(ADP ribose) polymerase (PARP) inhibitor. "

11/09/2016 - "WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells."

04/29/2014 - "However, anti-tumour activity of MIRA-1 in haematological malignancies including multiple myeloma (MM) is unknown. "

01/25/2011 - "A small molecule from the National Cancer Institute Diversity Set designated NSC 19630 [1-(propoxymethyl)-maleimide] was identified that inhibited WRN helicase activity but did not affect other DNA helicases [Bloom syndrome (BLM), Fanconi anemia group J (FANCJ), RECQ1, RecQ, UvrD, or DnaB). "

01/25/2011 - "A small molecule from the National Cancer Institute Diversity Set designated NSC 19630 [1-(propoxymethyl)-maleimide] was identified that inhibited WRN helicase activity but did not affect other DNA helicases [Bloom syndrome (BLM), Fanconi anemia group J (FANCJ), RECQ1, RecQ, UvrD, or DnaB). "