2,6- dichloro- 9- (1- (p- nitrobenzenesulfonyl)- 1,2,3,5- tetrahydro- 4,1- benzoxazepin- 3- yl)- 9H- purine

06/15/2014 - "These findings support further studies on the therapeutic potential of Bozepinib in cancer patients. "
06/15/2014 - "Finally, Bozepinib shows in vivo anti-tumor and anti-metastatic efficacy in xenotransplanted nude mice without presenting sub-acute toxicity. "
07/01/2021 - "Recent studies show that bozepinib (BZP), a purine derivative, has potential applications in cancer treatment. "
10/31/2023 - "Bozepinib (BZP), a purine-derived molecule, is a potential compound for the treatment of cancer. "
06/15/2014 - "HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound."

06/15/2014 - "The cytotoxic effects of Bozepinib were observed in both breast and colon cancer cells expressing different receptor patterns. "
01/01/2013 - "However, p53 was not affected by bozepinib, and was not necessary for induction of apoptosis in either breast or colon cancer cells. "
01/01/2013 - "In the present study, we show that bozepinib also has antitumor activity in colon cancer cells, showing 50% inhibitory concentration (IC50) values lower than those described for breast cancer cells and suggesting great potential of this synthetic drug in the treatment of cancer. "

01/01/2013 - "Bozepinib [(RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-9H-purine] is a potent antitumor compound that is able to induce apoptosis in breast cancer cells. "
01/01/2013 - "In the present study, we show that bozepinib also has antitumor activity in colon cancer cells, showing 50% inhibitory concentration (IC50) values lower than those described for breast cancer cells and suggesting great potential of this synthetic drug in the treatment of cancer. "

07/01/2021 - "New insights into cytotoxic mechanisms of bozepinib against glioblastoma."
10/01/2021 - "Development of bozepinib-loaded nanocapsules for nose-to-brain delivery: preclinical evaluation in glioblastoma."
10/01/2021 - "Aim: To develop and characterize bozepinib-loaded lipid-core nanocapsules (BZP-LNC+) as a potential treatment for glioblastoma (GBM). "

06/15/2014 - "Moreover, the modulation of pathways involved in tumorigenesis by Bozepinib was also evident in microarrays analysis. "
06/15/2014 - "In the present work we show how Bozepinib [(RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-9H-purine], a small anti-tumor compound, demonstrated selectivity on cancer cells and showed an inhibitory effect over kinases involved in carcinogenesis, proliferation and angiogenesis. "