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N'- (3,5- bis(trifluoromethyl)phenyl)- 2- (hexahydropyrrolo(1,2- a)pyrazin- 2(1H)- yl)- 2- (3- pyridinyl)ethanohydrazide

structure in first source

Also Known As:

GSK 1614343; GSK-1614343; GSK1614343

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrazines: 379
  - N'-(3,5-bis(trifluoromethyl)phenyl)-2-(hexahydropyrrolo(1,2-a)pyrazin-2(1H)-yl)-2-(3-pyridinyl)ethanohydrazide: 2
- Aza Compounds: 3
  - Azabicyclo Compounds
    - N'-(3,5-bis(trifluoromethyl)phenyl)-2-(hexahydropyrrolo(1,2-a)pyrazin-2(1H)-yl)-2-(3-pyridinyl)ethanohydrazide: 2
Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - Azabicyclo Compounds
      - N'-(3,5-bis(trifluoromethyl)phenyl)-2-(hexahydropyrrolo(1,2-a)pyrazin-2(1H)-yl)-2-(3-pyridinyl)ethanohydrazide: 2

Experts

1.	Corsi, Mauro: 2 articles (01/2011 - 01/2011)
2.	Buson, Alberto: 1 article (01/2011)
3.	Corti, Corrado: 1 article (01/2011)
4.	Faggioni, Federico: 1 article (01/2011)
5.	Perdonà, Elisabetta: 1 article (01/2011)
6.	Sabbatini, Fabio Maria: 1 article (01/2011)
7.	Bifone, Angelo: 1 article (01/2011)
8.	Costantini, Vivian J A: 1 article (01/2011)
9.	Lepore, Stefano: 1 article (01/2011)
10.	Melotto, Sergio: 1 article (01/2011)

Related Diseases

1.	Weight Gain 01/01/2011 - "Taken together, these results indicate that the orexigenic effect of GSK1614343 is mediated by GHSR1a and that the weight gain could be attributed to the increase of both adiposity and muscle mass, but not to fluid retention. "
2.	Pituitary Neoplasms (Pituitary Adenoma) 01/10/2011 - "A novel growth hormone secretagogues type 1a (GHS1a) receptors antagonist (2R)-N'-[3,5- bis(trifluoromethyl)phenyl]-2-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-(3- pyridinyl)ethanohydrazide (GSK1614343) was functionally characterised in rat pituitary adenoma cell line, RC-4B/C endogenously expressing GHS1a receptors. "
3.	Body Weight (Weight, Body) 01/01/2011 - "GSK1614343, a novel ghrelin receptor antagonist, produces an unexpected increase of food intake and body weight in rodents and dogs."

Related Drugs and Biologics

1.	Ghrelin Receptors
2.	Growth Hormone (Somatotropin)
3.	Secretagogues