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STF 083010

inhibits Ire1 endonuclease; structure in first source

Also Known As:

STF-083010; STF083010

Networked: 17 relevant articles (4 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - STF 083010: 17
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - STF 083010: 17
  - Thiophenes: 257
    - STF 083010: 17
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - STF 083010: 17

Experts

1.	Huang, Juan: 2 articles (06/2022 - 05/2020)
2.	Lu, Weitian: 2 articles (06/2022 - 05/2020)
3.	Tang, Jiping: 2 articles (05/2020 - 02/2018)
4.	Zhang, John H: 2 articles (05/2020 - 02/2018)
5.	Gan, Shengwei: 1 article (06/2022)
6.	Liao, Yuhui: 1 article (06/2022)
7.	Shu, Yue: 1 article (06/2022)
8.	Xu, Shiye: 1 article (06/2022)
9.	Yang, Zhengyu: 1 article (06/2022)
10.	Zhu, Shujuan: 1 article (06/2022)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2015 - "Moreover, co-treatment with STF-083010 and tamoxifen can significantly delay breast cancer progression in a xenograft mammary tumor model. " 01/01/2018 - "However, combining STF-083010 and chloroquine had additive anti-tumor efficacy when used with gemcitabine. " 09/01/2017 - "More importantly, ERs inhibitor 4-PBA, IRE1α inhibitor STF-083010, ATF6 inhibitor Anti-ATF6 and PERK inhibitor GSK2656157 can all reduce the amplitude of protein expression changes and apoptosis rates, then weaken the anti-tumor effect of β-elemene. "
2.	Infarction (Infarctions) 05/06/2020 - "STF083010 administration significantly upregulated the expression of miR-125-b-2-3p, reduced the infarct volume, improved neurobehavioral outcomes and downregulated the protein expression of NLRP1, cleaved caspase-1, IL-1β and IL-18. "
3.	Hematoma 06/01/2022 - "Inhibition of IRE1α, with STF083010, remarkably reduced brain water content, improved neurological function, decreased hematoma volume, upregulated the expression of miR-125b-2-3p, decreased the number of mast cells, and downregulated the protein expression of Lyn kinase, XBP1s (spliced X-box binding protein-1), tryptase, IL-17A and TNF-α. "
4.	Brain Injuries (Brain Injury) 02/02/2018 - "Intranasal administration of STF-083010 alleviated brain injury and improved neurological behavior. "
5.	Liver Cirrhosis (Hepatic Cirrhosis) 01/01/2018 - "This study provides partial evidence that STF-083010 alleviated CCl4-induced liver injury and thus protected against liver fibrosis associated with hepatic miR-122." 01/01/2018 - "This study aimed to explore the effects of STF-083010 on carbon tetrachloride (CCl4)-induced liver injury and subsequent liver fibrosis. " 01/01/2018 - "CCl4-induced hepatic hydroxyproline and collagen I, major indicators of liver fibrosis, were alleviated by STF-083010. " 01/01/2018 - "Inositol-Requiring Enzyme 1 Alpha Endoribonuclease Specific Inhibitor STF-083010 Alleviates Carbon Tetrachloride Induced Liver Injury and Liver Fibrosis in Mice."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Chloroquine (Aralen)
3.	Tryptases (Tryptase)
4.	Interleukin-18 (Interleukin 18)
5.	Interleukin-17 (Interleukin 17)
6.	Phosphotransferases (Kinase)
7.	Gemcitabine
8.	X-Box Binding Protein 1
9.	Carbon Tetrachloride (Tetrachloromethane)
10.	Ribonucleases (Ribonuclease)

Related Therapies and Procedures

1.	Intranasal Administration
2.	Aftercare (After-Treatment)