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copalic acid

a trypanocidal agent isolated from Aristolochia cymbifera; structure in first source

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - copalic acid: 4

Experts

1.	Bastos, Jairo K: 2 articles (11/2011 - 02/2011)
2.	Furtado, Niege A J C: 2 articles (11/2011 - 02/2011)
3.	Heleno, Vladimir C G: 2 articles (11/2011 - 02/2011)
4.	Martins, Carlos H G: 2 articles (11/2011 - 02/2011)
5.	Souza, Ariana B: 2 articles (11/2011 - 02/2011)
6.	Veneziani, Rodrigo C S: 2 articles (11/2011 - 02/2011)
7.	Ashcraft, Morgan M: 1 article (01/2017)
8.	Gan, Chunfang: 1 article (01/2017)
9.	Idippily, Nethrie D: 1 article (01/2017)
10.	Quamine, Aicha: 1 article (01/2017)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 01/01/2017 - "To develop potent drug candidates to decrease the AR level in prostate cancer cells, more copalic acid analogs were synthesized. "
2.	Infections 12/21/2015 - "The diterpene (-)-copalic acid is a potential lead for the development of new selective antimicrobial agents to treat infections caused by Gram-positive multiresistant microorganisms, in both the sessile and planktonic mode. "
3.	Glioblastoma (Glioblastoma Multiforme) 12/21/2015 - "The most pronounced antiproliferative effect arose in tumor cell lines treated with (-)-copalic acid; the lowest IC50 value was found for the human glioblastoma cell line. "
4.	Dental Caries (Decay, Dental) 02/01/2011 - "Among these metabolites, (-)-copalic acid (CA) was the most active compound displaying MIC values very promising (ranging from 2.0 to 6.0 µg/mL) against the main microorganisms responsible for dental caries: Streptococcus salivarius, S. "
5.	Communicable Diseases (Infectious Diseases) 11/18/2011 - "Among all the evaluated compounds, (-)-copalic acid (CA) was the most active, displaying a very promising MIC value (3.1 µg mL-1; 10.2 µM) against the key pathogen (Porphyromonas gingivalis) involved in this infectious disease. "

Related Drugs and Biologics

1.	Diterpenes
2.	Anti-Infective Agents (Microbicides)