p-chloro-o-toluidine hydrochloride

structure in first source

Also Known As:

4-chloro-2-methylaniline; 4-chloro-2-methylaniline hydrochloride; 4-chloro-2-toluidine; 4-chloro-2-toluidine hydrochloride; 4-chloro-o-toluidine; p-chloro-o-toluidine; Benzenamine, 4-chloro-2-methyl-, hydrochloride (1:1)

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - Toluidines: 2
      - p-chloro-o-toluidine hydrochloride: 5
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Toluene: 931
        Toluidines: 2
        p-chloro-o-toluidine hydrochloride: 5

Related Diseases

1.	Neoplasms (Cancer) 01/01/1988 - "In an historical mortality study, conducted on a cohort of 335 male employees in 4-chloro-o-toluidine (4-COT) production and processing plants, no deaths due to cancer of the urinary bladder had been identified. "
2.	Necrosis 12/01/2023 - "Histopathological analysis revealed that seven aromatic amines, including 4-chloro-o-toluidine (4-CT), o-aminoazotoluene, 2-aminobenzyl alcohol (ABA), o-acetotoluidine (o-AT), 3,3'-dimethoxybenzidine, 4-aminoazobenzene (AAB), and 4,4'-methylenedianiline (MDA), induced various bladder lesions, such as hemorrhage, necrosis, and urothelial hyperplasia. "
3.	Hyperplasia 12/01/2023 - "Histopathological analysis revealed that seven aromatic amines, including 4-chloro-o-toluidine (4-CT), o-aminoazotoluene, 2-aminobenzyl alcohol (ABA), o-acetotoluidine (o-AT), 3,3'-dimethoxybenzidine, 4-aminoazobenzene (AAB), and 4,4'-methylenedianiline (MDA), induced various bladder lesions, such as hemorrhage, necrosis, and urothelial hyperplasia. "
4.	Hemorrhage 12/01/2023 - "Histopathological analysis revealed that seven aromatic amines, including 4-chloro-o-toluidine (4-CT), o-aminoazotoluene, 2-aminobenzyl alcohol (ABA), o-acetotoluidine (o-AT), 3,3'-dimethoxybenzidine, 4-aminoazobenzene (AAB), and 4,4'-methylenedianiline (MDA), induced various bladder lesions, such as hemorrhage, necrosis, and urothelial hyperplasia. "
5.	Hemangiosarcoma (Angiosarcoma) 01/01/1979 - "It is concluded that under the conditions of this bioassay, 4-chloro-o-toluidine hydrochloride was not carcinogenic for F344 rats but was carcinogenic for B6C3F1 mice, including hemangiosarcomas and hemangiomas in both males and females. "

Related Drugs and Biologics

1.	o-Aminoazotoluene
2.	Dianisidine
3.	Chlorphenamidine (Chlordimeform)
4.	Amines
5.	2-aminobenzyl alcohol
6.	4,4'-diaminodiphenylmethane